Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans.

Blood
Hideki NakasoneDavid B Miklos

Abstract

Allogeneic antibodies against minor histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell transplant (HCT) of male recipients with female donors (F→M). However, the temporal association between HY-Ab development and chronic graft-versus-host disease (cGVHD) has yet to be elucidated. We studied 136 adult F→M HCT patients, with plasma prospectively collected through 3 years posttransplant, and measured immunoglobulin G against 6 H-Y antigens. Multiple HY-Abs were frequently detected beginning at 3 months posttransplant: 78 (57%) of F→M patients were seropositive for at least 1 of the 6 HY-Abs, and 3-month seropositivity for each HY-Ab was associated with a persistent seropositive response throughout the posttransplant follow-up period (P < .001 in each). There were no associations between pretransplant features and 3-month overall HY-Ab development. Detection of multiple HY-Abs at 3 months (represented by HY score) was significantly associated with an increased risk of cGVHD (P < .0001) and nonrelapse mortality (P < .01). Compared to clinical factors alone, the addition of HY score to clinical factors improved the predictive potential of cGVHD (P < .01). Monitoring HY-Ab development thu...Continue Reading

References

Apr 30, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeMary E D Flowers
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Mar 23, 2006·Blood·Corey CutlerEdwin Alyea
Oct 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefanie SarantopoulosJerome Ritz
Apr 7, 2009·British Journal of Haematology·Voravit RatanatharathornUNKNOWN Center for International Blood and Marrow Transplant Research, Milwaukee, WI, USA
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Suzanne van DorpJürgen Kuball
Aug 18, 2009·Cancer Treatment Reviews·Voravit RatanatharathornJoseph P Uberti
Sep 15, 2009·Blood·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Apr 3, 2010·The Lancet Oncology·Ray Powles
Mar 4, 2011·Methods in Molecular Biology·Persis P WadiaDavid B Miklos
Sep 14, 2011·Current Opinion in Hematology·Yoshihiro Inamoto, Mary E D Flowers
Apr 10, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Giuseppe MessinaUNKNOWN Gruppo Italiano Trapianti di Midollo
Jun 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·James S YoungDefu Zeng
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bita SahafDavid B Miklos
Oct 1, 2013·Bone Marrow Transplantation·J KandaM Murata
May 2, 2014·Immunologic Research·Rakesh PopliDavid B Miklos
Jan 13, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Aaron C LoganUNKNOWN Center for International Blood and Marrow Transplantation

❮ Previous
Next ❯

Citations

Jan 26, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David A KnorrMichael R Verneris
Oct 13, 2015·Bone Marrow Transplantation·M I Abu ZaidD B Miklos
Feb 24, 2016·Journal of Immunological Methods·Jed PaulDavid Miklos
Oct 8, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kenneth R CookeBruce R Blazar
Dec 27, 2018·British Journal of Haematology·Xiaoping LiXi Zhang
Mar 31, 2015·International Journal of Hematology·Hideki NakasoneDavid B Miklos
Apr 5, 2017·Frontiers in Immunology·Sakhila GhimireErnst Holler
May 16, 2015·Blood·Tuna Mutis
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shi-Meng JiSheng-Li Xue
Dec 6, 2019·Frontiers in Oncology·Connor Sweeney, Paresh Vyas
Sep 3, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Roman Reindl-SchwaighoferRainer Oberbauer
Mar 16, 2021·Frontiers in Immunology·Chao HongXiaoming Gao
Jul 8, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kazuaki KamedaYoshinobu Kanda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.