PMID: 11916173Mar 28, 2002Paper

Allogeneic MHC class I ligands and their role in positive and negative regulation of human cytotoxic effector cells

Human Immunology
Christine S Falk, D J Schendel

Abstract

The allogeneic mixed lymphocyte culture (MLC) has served as an important experimental system for elucidating the cellular and molecular basis of human lymphocyte responses. Complex mixtures of lymphocytes are stimulated by disparate alloantigens, inducing cellular activation and generating a cytokine milieu that is an excellent breeding ground for the proliferation and differentiation of many distinct lymphocyte subsets. Cloning of individual lymphocytes following alloactivation has allowed various cytotoxic lymphocytes to be isolated and characterized with respect to phenotype and specificity. These analyses have revealed that all types of cytotoxic effector cells are regulated by interactions with MHC-peptide ligands, however, the consequences of these interactions can result in opposite functional outcomes. In this review we summarize how allogeneic MHC class I-peptide ligands positively or negatively regulate the activities of four distinct groups of cytotoxic lymphocytes and how this information might be transferred into clinical use.

References

Mar 1, 1992·International Immunology·S ManV H Engelhard
Oct 1, 1991·Current Opinion in Immunology·R Lechler, G Lombardi
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W R HeathL A Sherman
Mar 1, 1990·Immunology Today·R I LechlerF H Bach
Jul 1, 1995·Tissue Antigens·J G BodmerW R Mayr
Aug 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S G Marsh
Jan 1, 1993·Annual Review of Immunology·L A Sherman, S Chattopadhyay
Jan 1, 1995·Vox Sanguinis·J G BodmerW R Mayr
Sep 15, 1996·Human Immunology·P CarmichaelR Lechler
Feb 1, 1997·Current Opinion in Immunology·L L Lanier
Jun 1, 1997·Immunology Today·E Vivier, M Daëron
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A De MariaL Moretta
Nov 22, 1997·Current Opinion in Immunology·A Moretta, L Moretta
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M C MingariL Moretta
Mar 5, 1998·Nature·V M BraudA J McMichael
Dec 29, 1998·Immunology Today·F Ruiz-Cabello, F Garrido
Feb 17, 1999·The British Journal of Dermatology·W M HowellJ M Theaker
Apr 22, 1999·Immunology Today·H J Stauss
Jun 8, 1999·Annual Review of Immunology·E O Long
Feb 5, 2000·Human Immunology·M López-BotetM de Miguel
Feb 5, 2000·Human Immunology·M Valés-GómezJ Strominger
Feb 5, 2000·Human Immunology·M BléryE Vivier
Feb 5, 2000·Human Immunology·I AlgarraF Garrido
Feb 5, 2000·Human Immunology·A De Maria, L Moretta
Mar 24, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L L Lanier
Apr 15, 2000·Seminars in Immunology·E O Long, S Rajagopalan
Apr 15, 2000·Seminars in Immunology·M López-BotetT Bellón

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.