Abstract
Allogeneic peripheral blood stem cell (PBSC) transplant has recently been introduced for the treatment of hematological malignancies. As the data were limited mainly to adult patients, this study aimed to assess the feasibility and safety of this procedure in pediatric patients and donors. Eleven children aged 2-16 years received allogeneic PBSC transplant for acute lymphoblastic leukemia (n = 4), acute myeloid leukemia (n = 1), myelodysplastic syndrome (n = 1), severe aplastic anemia (n = 3), and thalassemia (n = 2). Nine donors were human leukocyte antigen (HLA)-identical siblings and the other two were one antigen mismatched family members. Eight donors were younger than 18 years old (10 months to 17 years). Donors were primed with granulocyte colony-stimulating factor (G-CSF) at 10-16 micrograms/kg for 4-5 days. Aphereses were performed on 1 or 2 consecutive days, and the patients received a mean of 14.4 x 10(8)/kg nucleated cells, 6.9 x 10(6)/kg CD34 cells, and 6.9 x 10(8)/kg T cells. All patients achieved neutrophil counts of > 0.5 x 10(9)/l at a median of 16 days. Nine patients achieved platelet counts of > 20 x 10(9)/l at a median of 13 days. Grade II acute graft vs. host disease (GVHD) occurred in only one patient. Chr...Continue Reading
References
Mar 14, 1992·Lancet·W P SheridanR M Fox
Feb 1, 1992·Acta Paediatrica·J HeldrupK Prellner
Jun 20, 1991·The New England Journal of Medicine·J NemunaitisM Gold
Oct 1, 1974·Transplantation·H GlucksbergE D Thomas
Jan 1, 1995·British Journal of Haematology·S ImashukuS Todo
Nov 10, 1994·The New England Journal of Medicine·A J BarrettP A Rowlings
Jun 1, 1996·British Journal of Haematology·N RusselN Schmitz
Mar 1, 1997·Bone Marrow Transplantation·A GratwohlH Baldomero
Citations
Feb 17, 1999·The Journal of Experimental Medicine·T MatternA J Ulmer
Feb 23, 1999·British Journal of Haematology·K LiP M Yuen
Dec 22, 1999·Transfusion·K S TsangP M Yuen
Aug 14, 2012·Pediatric Transplantation·Saskia L GooskensMarry M van den Heuvel-Eibrink
Jun 11, 2010·Pediatric Transplantation·Frankie Wai Tsoi ChengTing Fan Leung
Nov 24, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Julián SevillaLuis Madero
Jul 26, 2003·Cytotherapy·A VerdeguerV Castel
Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kasiani C Myers, Stella M Davies
Feb 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ardeshir GhavamzadehKamran Alimoghaddam
Mar 1, 2000·Medical and Pediatric Oncology·T WatanabeY Kuroda
Aug 31, 2002·Journal of Hematotherapy & Stem Cell Research·Julián SevillaMiguel Angel Díaz
Jul 10, 2002·Bone Marrow Transplantation·M G VicentUNKNOWN Spanish Working Party for BMT in Children (GETMON)
Nov 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary EapenJohn E Wagner
Feb 16, 2000·Bone Marrow Transplantation·T F LeungP M Yuen
Sep 1, 2000·Bone Marrow Transplantation·L MaderoM A Díaz
Oct 19, 2001·Bone Marrow Transplantation·A I BenitoM A Diaz
Jan 10, 2002·Bone Marrow Transplantation·M A YesilipekO Yegin
Feb 27, 2001·Bone Marrow Transplantation·M A DíazF Deméocq
Feb 28, 2008·Current Opinion in Oncology·Ebru Koca, Richard E Champlin