Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

Eye
C-C ChiangY-Y Tsai

Abstract

To evaluate the efficacy and safety of allogeneic serum in the treatment of persistent corneal epithelial defect (PED). Thirty-six patients with PED whose autologous serum was unavailable or unsuitable for use were included in the study. Blood was obtained from the patients' family members who were healthy and had no history of hepatitis, bacteremia, or HIV. After standard serological testing used in blood transfusion, the allogeneic serum was prepared. The patients applied the serum eyedrops once every hour while awake and discontinued non-preservative artificial tears. If the epithelial defect was healing, the allogenic serum was gradually tapered. If the epithelial defect remained nearly the same size at day 14, amniotic membrane transplantation (AMT) was performed. Among the 36 patients, the epithelial defect healed in 6 patients (16.7%) within 1 week, in an additional 9 patients (25%) in 1-2 weeks, totaling 15 patients (41.7%) within 2 weeks. Twenty-one patients (58.3%) did not completely heal at the second week. Among these 21 patients, 10 (27.8%) underwent AMT and had subsequent healing of the epithelial defect, 8 completely healed within 1 month, and the remaining 3 healed within 2 months. None of the 36 patients report...Continue Reading

References

Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G B van SettenJ Perheentupa
May 1, 1986·Arthritis and Rheumatism·R I FoxF V Howell
Dec 24, 1997·American Journal of Ophthalmology·S C Tseng, K Tsubota
Aug 6, 1999·The British Journal of Ophthalmology·K TsubotaS Shimmura
Aug 6, 1999·The British Journal of Ophthalmology·A Azuara-BlancoH S Dua
Dec 3, 1999·Klinika oczna·J Markuszewska, P Krzyzanowska
Sep 25, 2001·The British Journal of Ophthalmology·A C PoonJ T Daniels
Nov 12, 2003·The British Journal of Ophthalmology·R B VajpayeeS A Melki
Jun 5, 2004·Ophthalmology·Yukihiro MatsumotoKazuo Tsubota
Oct 19, 2004·The British Journal of Ophthalmology·G GeerlingD Hartwig
Aug 1, 2006·American Journal of Ophthalmology·Stephan D SchulzePeter Kroll

❮ Previous
Next ❯

Citations

Jul 9, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G GeerlingD Hartwig
Feb 6, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jerard SeghatchianThierry Burnouf
Feb 6, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Pieter F van der MeerDenese C Marks
Jul 17, 2015·The British Journal of Ophthalmology·Nishant G Soni, Bennie H Jeng
Apr 20, 2010·Clinical & Experimental Ophthalmology·Harminder S DuaDalia G Said
Jun 29, 2010·American Journal of Ophthalmology·Yan-Ming ChenWei-Li Chen
Jun 2, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·A EspinosaJ Seghatchian
Jul 1, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Denese C MarksPeta M Dennington
Jun 17, 2015·Survey of Ophthalmology·Ryan B Nugent, Graham A Lee
Oct 16, 2016·Journal français d'ophtalmologie·V KocabaC Burillon
Dec 3, 2016·Scientific Reports·Kaevalin LekhanontVarintorn Chuckpaiwong
Dec 3, 2016·Eye·E AnituaG Orive
Sep 25, 2020·Ophthalmology and Therapy·Ali E GhareebFrancisco C Figueiredo
Mar 13, 2018·Frontiers in Medicine·Victor J DrewThierry Burnouf
Jun 2, 2018·Journal of Ophthalmology·Sang Beom HanJodhbir S Mehta
Apr 18, 2017·Journal of the American Veterinary Medical Association·J Seth EatonDavid J Maggs
Sep 20, 2019·Journal of Clinical Medicine·Federico BernabeiPiera Versura
Oct 17, 2020·Vestnik oftalmologii·S V TrufanovN P Shakhbazyan
Feb 17, 2021·Acta Ophthalmologica·Pieter F van der MeerCatharina A Eggink
Apr 11, 2021·BMJ Case Reports·Rathin PujariMadhavan S Rajan
Nov 22, 2019·The British Journal of Ophthalmology·Chin-Te HuangWei-Li Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.