Allogeneic Stem Cell Transplantation in Myelofibrosis.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Tania JainJeanne M Palmer

Abstract

Myeloproliferative neoplasm (MPN) is a category in the World Health Organization classification of myeloid tumors. BCR-ABL1-negative MPN is a subcategory that includes primary myelofibrosis (MF), post-essential thrombocythemia MF, and post-polycythemia vera MF. These disorders are characterized by stem cell-derived clonal myeloproliferation. Clinically, these diseases present with anemia and splenomegaly and significant constitutional symptoms such as severe fatigue, symptoms associated with an enlarged spleen and liver, pruritus, fevers, night sweats, and bone pain. Multiple treatment options may provide symptom relief and improved survival; however, allogeneic stem cell transplantation (HCT) remains the only potentially curative option. The decision for a transplant is based on patient prognosis, age, comorbidities, and functional status. This review describes the recent data on various peritransplantation factors and their effect on outcomes of patients with MF and new therapeutic areas, such as the use and timing of Janus kinase inhibitors with HCT and gives overall conclusions from the available data in the published literature.

Citations

Feb 8, 2019·The Journal of Clinical Investigation·Simona StivalaSara C Meyer
Sep 20, 2019·Bone Marrow Transplantation·Mario TiribelliMassimiliano Bonifacio
May 10, 2020·Blood Advances·Krisstina GowinWael Saber
Oct 7, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeanne PalmerRuben Mesa
Jan 27, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Saurabh ChhabraParameswaran N Hari
May 8, 2021·World Journal of Stem Cells·Nassem Ahamad, Brij B Singh
Jul 2, 2021·Journal of Hematology & Oncology·Graeme GreenfieldKen Mills
Sep 20, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Isik Kaygusuz AtagunduzNicolaus Kröger
Dec 28, 2021·Hematology·Timothy DevosFleur Samantha Benghiat

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