Allogeneic transplantation for Hodgkin lymphoma

British Journal of Haematology
Karl S PeggsA Sureda

Abstract

The majority of patients with Hodgkin lymphoma (HL) can now expect to be cured with conventional chemo- and/or radio-therapy. However, a subgroup still exists that have poor outcomes, even following dose escalation and autologous stem cell transplantation. Furthermore, patients relapsing after autografting have limited therapeutic options available. Whilst the application of allogeneic transplantation strategies has historically been limited by prohibitive transplant-related mortality, the exploration of reduced intensity approaches has demonstrated the feasibility of delivering allogeneic immunotherapies with more acceptable mortality rates. Although its role remains controversial, we are beginning to re-evaluate the use of allogeneic transplantation in the management of patients with HL and to address a number of critical questions. These include whether a clinically relevant graft-versus-tumour response occurs in HL, and whether subgroups of patients who might benefit from allogeneic approaches can be identified in order to inform development of rational clinical studies. This review focuses on evaluating recent experience with reduced intensity allogeneic approaches in HL in order to inform opinion on its current role and t...Continue Reading

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Citations

Mar 6, 2012·The Oncologist·Radhakrishnan Ramchandren
Aug 29, 2014·Stem Cells International·Gregory E TullisMark D Kirk
Feb 6, 2014·British Journal of Haematology·Girish VenkataramanVolker Diehl
Jul 2, 2016·Clinical Lymphoma, Myeloma & Leukemia·Amir K Issa, Jason R Westin

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