Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study

Stem Cells Translational Medicine
Daniel T LaskowitzJoanne Kurtzberg

Abstract

Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are eligible for this therapy. We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. To investigate this, we conducted a phase I open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients. Ten participants with acute middle cerebral artery ischemic stroke were enrolled. UCB units were matched for blood group antigens and race but not HLA, and infused 3-9 days post-stroke. The adverse event (AE) profile over a 12 month postinfusion period indicated that the treatment was well-tolerated in these stroke patients, with no serious AEs directly related to the study product. Study participants were also assessed using neurological and functional evaluations, including the modified Rankin Score (mRS) and National Institute of Health Stroke Scale (N...Continue Reading

Associated Clinical Trials

Mar 24, 2015·Joanne Kurtzberg, MD

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·R Bonita, R Beaglehole
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Feb 15, 2001·Neuroepidemiology·S M Lai, P W Duncan
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·C S KidwellJ L Saver
Jul 18, 2003·Journal of Neuroscience Research·A E WillingP R Sanberg
Jul 26, 2003·Archives of Physical Medicine and Rehabilitation·Peter J KellyJoel Stein
Jun 21, 2005·Annals of the New York Academy of Sciences·Zhenhong NanWalter C Low
Aug 27, 2005·Journal of Neurosurgery·Douglas KondziolkaJeffrey Teraoka
Apr 19, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adam DenesStuart M Allan
Jun 20, 2007·Neurochemistry International·Alan S Hazell
Jun 30, 2007·Stroke; a Journal of Cerebral Circulation·Terence J QuinnMatthew R Walters
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Apr 29, 2009·The Journal of Comparative Neurology·Terry C BurnsWalter C Low
Aug 24, 2010·Critical Reviews in Oncology/hematology·Young-June Kim, Hal E Broxmeyer
Jun 12, 2012·Expert Opinion on Biological Therapy·Hongyan ZhouMahendra Rao
Jul 6, 2012·Stroke; a Journal of Cerebral Circulation·Francisco MonicheAlberto Gil-Peralta
Sep 14, 2012·Stem Cells and Development·Farhaan S VahidySean I Savitz
Jan 4, 2013·Stem Cells Translational Medicine·Matthias ReitzNils Ole Schmidt
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Sean I Savitz, Heinrich P Mattle
May 23, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·David C HessRobert W Mays
Sep 13, 2013·The Cochrane Database of Systematic Reviews·UNKNOWN Stroke Unit Trialists' Collaboration
Nov 14, 2013·Clinical & Developmental Immunology·Roslyn A Taylor, Lauren H Sansing
Jan 23, 2014·Lancet·Valery L FeiginUNKNOWN Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group
Apr 10, 2014·Nature Reviews. Neuroscience·Marco Prinz, Josef Priller
Aug 12, 2014·Stem Cells Translational Medicine·Soma BanerjeeJeremy Chataway
Nov 8, 2014·Stroke; a Journal of Cerebral Circulation·Kameshwar PrasadUNKNOWN InveST Study Group
Dec 18, 2014·The New England Journal of Medicine·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators
Feb 12, 2015·The New England Journal of Medicine·Bruce C V CampbellUNKNOWN EXTEND-IA Investigators
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Mar 25, 2015·Cytotherapy·Jessica M Sun, Joanne Kurtzberg
Mar 31, 2015·Journal of the Neurological Sciences·Adriana Octaviana Dulamea
Apr 18, 2015·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN SWIFT PRIME Investigators
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
Jul 30, 2015·Stroke; a Journal of Cerebral Circulation·Sandra A AcostaCesar V Borlongan

❮ Previous
Next ❯

Citations

May 6, 2019·The Cochrane Database of Systematic Reviews·Giorgio Battista BoncoraglioCinzia Del Giovane
Feb 27, 2019·Current Stem Cell Research & Therapy·David T Harris, Scott Israel
Aug 3, 2019·Transfusion·Sergio Querol, Dinara Samarkanova
Jul 4, 2020·Stem Cells Translational Medicine·Tamila L Kindwall-Keller, Karen K Ballen
Jan 24, 2019·Journal of Clinical Medicine·Katherine S BrownHeather L Brown
May 16, 2019·Bone Marrow Transplantation·Hector MayaniHal E Broxmeyer
Jun 12, 2019·Cell Transplantation·Paul R Sanberg, Jared Ehrhart
Jun 26, 2020·Frontiers in Neuroscience·Manisha SinghSujata Mohanty
Nov 8, 2018·Stem Cells Translational Medicine·Stuart P Atkinson
Jul 12, 2019·Frontiers in Neurology·Mirja KrauseRebecca Lim
Oct 30, 2019·Brain Sciences·Matthew R ChrostekAndrew W Grande
Oct 11, 2020·International Journal of Molecular Sciences·Masahito KawaboriKiyohiro Houkin
Feb 3, 2021·British Journal of Haematology·Andromachi Scaradavou
Dec 31, 2020·Genes·Paz de la Torre, Ana I Flores
Jan 1, 2021·Frontiers in Aging Neuroscience·Joy Q HeGary K Steinberg
Apr 2, 2020·Current Stem Cell Research & Therapy·Xiaojie BaiHong Zhang
Feb 27, 2021·Frontiers in Cellular Neuroscience·Weifeng LiYuelin Zhang
Mar 18, 2021·Curēus·Abba Musa AbdullahiArpita Bhriguvanshi
Apr 21, 2021·British Journal of Haematology·Sergio QuerolAlejandro Madrigal
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Guoyang ZhouLin Wang
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Fernando José Rascón-RamírezLeyre Sánchez-Sánchez-Rojas
Aug 16, 2021·Brain Research Bulletin·Juhi Samal, Tatiana Segura

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Clinical Trials Mentioned

NCT03004976

Software Mentioned

MultiStem

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.