Allogenic banking of dental pulp stem cells for innovative therapeutics

World Journal of Stem Cells
Pierre-Yves Collart-DutilleulFrédéric Cuisinier

Abstract

Medical research in regenerative medicine and cell-based therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells (DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products (ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen (HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues (dental pulps) as a source of mesenchymal stem cells to p...Continue Reading

Citations

Jul 25, 2017·Journal of Neuroscience Research·Ibrahim MortadaMohamad Al Bazzal
Mar 23, 2018·International Journal of Molecular Sciences·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
Feb 22, 2017·World Journal of Gastrointestinal Pharmacology and Therapeutics·Shogo OhkoshiKatsuhiko Hasegawa
Oct 6, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Edgar Ledesma-MartínezEdelmiro Santiago-Osorio
Apr 14, 2018·Stem Cell Research & Therapy·Hamideh SalehiValerie Orti
Nov 6, 2018·World Journal of Hepatology·Shogo OhkoshiHiroshi Ishikawa
Aug 28, 2021·International Journal of Molecular Sciences·Zhuo XieZhengmei Lin

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