Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells

JCI Insight
Hidetoshi TsudaRobert L Fairchild

Abstract

Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior to organ transplantation increase early posttransplant inflammation and negatively impact early graft function and long-term graft outcome. Little is known about the mechanisms enhancing endogenous memory T cell activation to mediate tissue injury within the increased inflammatory environment of allografts subjected to prolonged cold ischemic storage (CIS). Endogenous memory CD4+ and CD8+ T cell activation is markedly increased within complete MHC-mismatched cardiac allografts subjected to prolonged versus minimal CIS, and the memory CD8+ T cells directly mediate CTLA-4Ig-resistant allograft rejection. Memory CD8+ T cell activation within allografts subjected to prolonged CIS requires memory CD4+ T cell stimulation of graft DCs to produce p40 homodimers, but not IL-12 p40/p35 heterodimers. Targeting p40 abrogates memory CD8+ T cell proliferation within the allografts and their ability to mediate CTLA-4Ig-resistant allograft rejection. These findings indicate a critical role for memory CD4+ T cell-graft DC interactions to increase...Continue Reading

References

Aug 1, 1992·Cellular Immunology·M K GatelyR Chizzonite
Aug 10, 1995·The New England Journal of Medicine·P I TerasakiS Takemoto
Jan 1, 1995·European Journal of Immunology·S GillessenM K Gately
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·B K ChoJ Chen
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna ValujskikhPeter S Heeger
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuan ZhaiJerzy W Kupiec-Weglinski
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael A BrehmRaymond M Welsh
Jun 19, 2003·The Journal of Clinical Investigation·Andrew B AdamsChristian P Larsen
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel L BarberRafi Ahmed
Nov 18, 2003·Immunological Reviews·Andrew B AdamsChristian P Larsen
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yifa ChenAnna Valujskikh
Oct 13, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kazuhito HonjoR Pat Bucy
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christian P LarsenRobert J Peach
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander A FilatenkovElizabeth Ingulli
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Joshua J AugustineDonald E Hricik
Jul 11, 2006·Immunological Reviews·Liisa K SelinRaymond M Welsh
Oct 6, 2007·Immunologic Research·Aaruni KhanolkarJohn T Harty
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D SchenkR L Fairchild
Aug 30, 2008·Transplantation·Nicholas R BannerUNKNOWN Steering Group of the United Kingdom Cardiothoracic Transplant Audit
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D SchenkA Valujskikh
Dec 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D IshiiR L Fairchild
Feb 18, 2010·Blood·Avital L AmirMirjam H M Heemskerk
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F VincentiC P Larsen
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DurrbachJ Grinyó
Apr 7, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SetoguchiR L Fairchild
Jun 10, 2011·Science Translational Medicine·Ognjenka NadazdinGilles Benichou
Aug 11, 2011·European Journal of Immunology·Selina J Keppler, Peter Aichele
Sep 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L K KaylerJ D Schold
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Dec 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Yuan ZhaiJerzy W Kupiec-Weglinski
May 17, 2013·The Journal of Clinical Investigation·Jeffrey M WalchFadi G Lakkis
Feb 8, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C A SuR L Fairchild
Jul 2, 2014·The Journal of Clinical Investigation·Martin H OberbarnscheidtFadi G Lakkis

❮ Previous
Next ❯

Citations

Oct 30, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shoichi IidaRobert L Fairchild
Oct 3, 2019·Current Opinion in Organ Transplantation·Anna B Morris, Mandy L Ford
Dec 7, 2019·Immunological Reviews·Christina R HartiganMandy L Ford
Feb 11, 2020·Transplantation·Michael NicosiaAnna Valujskikh
May 9, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Erik H KoritzinskyRobert L Fairchild

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry
FCS
ELISA

Software Mentioned

GraphPad
GraphPad Prism Pro

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
C A SuRobert L Fairchild
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S IidaRobert L Fairchild
The Journal of Immunology : Official Journal of the American Association of Immunologists
S IidaRobert L Fairchild
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K SetoguchiRobert L Fairchild
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K SetoguchiRobert L Fairchild
© 2022 Meta ULC. All rights reserved