Alloimmune and autoimmune background in recurrent pregnancy loss - successful immunotherapy by intravenous immunoglobulin

American Journal of Reproductive Immunology : AJRI
Beatrix KotlanGyozo Petranyi

Abstract

Immunotherapies [leukocyte immunization, intravenous immunoglobulin (IVIG)] introduced to treat women with recurrent spontaneous abortions (RSA) have still controversial results in most clinical trials. A selection of these patients would be advantageous for higher efficacy. A complex immunological panel assay was offered to patients with reproductive failure without any other known cause. We focused here on the cellular immunological parameters. High cytotoxic T lymphocyte precursor frequency and cell-mediated cytotoxic activity and a rather high natural killer cell activity were found in alloimmune RSA patients. Thirty-two patients were investigated by immunological assays and in 78% of the women an alloimmune background could be defined. The efficacy of IVIG treatment was 96% in this group. The novel cellular immunological assays proved to be favourable for the indication of RSA patients and showed the usefulness of this selection process for effective immunotherapy.

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Citations

Nov 13, 2009·Clinical Reviews in Allergy & Immunology·Caterina De CarolisRoberto Perricone
Oct 30, 2015·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Dec 27, 2011·Journal of Reproductive Immunology·A S BansalM Y Thum
Dec 17, 2015·Archives of Gynecology and Obstetrics·Lili MengJianping Zhang
Sep 16, 2009·The Journal of Obstetrics and Gynaecology Research·Joanne Kwak-KimAlice Gilman-Sachs
May 10, 2013·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Feb 3, 2012·American Journal of Reproductive Immunology : AJRI·Gavin SacksMichael Chapman
Jan 18, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joëlle Gregoire-GauthierElie Haddad
Mar 21, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Aiko SasakiKoushi Yamaguchi
Dec 15, 2015·International Journal of Immunopathology and Pharmacology·P TriggianeseC De Carolis
Feb 10, 2018·Evolution, Medicine, and Public Health·Robert BayersdorfFrancesco Catania
Apr 26, 2018·Reproductive Medicine and Biology·Ae R Han, Sung K Lee
Dec 17, 2014·The Journal of Biological Chemistry·Kiyomi MizugishiKouhei Yamashita

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