Allometric scaling for predicting human clearance of bisphenol A

Toxicology and Applied Pharmacology
Séverine H ColletVéronique Gayrard

Abstract

The investigation of interspecies differences in bisphenol A (BPA) pharmacokinetics (PK) may be useful for translating findings from animal studies to humans, identifying major processes involved in BPA clearance mechanisms, and predicting BPA PK parameters in man. For the first time, a large range of species in terms of body weight, from 0.02 kg (mice) to 495 kg (horses) was used to predict BPA clearance in man by an allometric approach. BPA PK was evaluated after intravenous administration of BPA in horses, sheep, pigs, dogs, rats and mice. A non-compartmental analysis was used to estimate plasma clearance and steady state volume of distribution and predict BPA PK parameters in humans from allometric scaling. In all the species investigated, BPA plasma clearance was high and of the same order of magnitude as their respective hepatic blood flow. By an allometric scaling, the human clearance was estimated to be 1.79 L/min (equivalent to 25.6 mL/kg.min) with a 95% prediction interval of 0.36 to 8.83 L/min. Our results support the hypothesis that there are highly efficient and hepatic mechanisms of BPA clearance in man.

References

May 1, 1981·British Journal of Clinical Pharmacology·T K DaneshmendC J Roberts
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K K Chan, M Gibaldi
Apr 13, 2000·Journal of Clinical Pharmacology·P L Bonate, D Howard
Oct 22, 2002·Chemical Research in Toxicology·Wolfgang VölkelWolfgang Dekant
Oct 24, 2002·Gerontology·Abhinandana AnantharajuAntonio Chedid
Nov 7, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Chang Youn ChoSun Dong Yoo
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hiroki InoueSeiyu Kato
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Beom Soo ShinSun Dong Yoo
Jun 17, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn
Jun 3, 2008·Physiological and Biochemical Zoology : PBZ·Gary C Packard, Thomas J Boardman
Jun 30, 2009·Toxicology Letters·Hans Mielke, Ursula Gundert-Remy
Mar 20, 2010·Journal of Exposure Science & Environmental Epidemiology·Judy S Lakind, Daniel Q Naiman
Mar 27, 2010·Environmental Health Perspectives·Laura N VandenbergGilbert Schoenfelder
Jul 27, 2010·Toxicology and Applied Pharmacology·Daniel R DoergeJeffrey W Fisher
Aug 26, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Christopher S MazurJohn C Lipscomb
May 17, 2011·Toxicology Letters·H MielkeU Gundert-Remy
Oct 25, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frederick S Vom SaalWade V Welshons
Jun 14, 2013·Environmental Health Perspectives·Véronique GayrardNicole Picard-Hagen
Jul 6, 2014·Expert Opinion on Drug Metabolism & Toxicology·Qingbiao Huang, Jim E Riviere

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Citations

Apr 20, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Davy GuignardCatherine Viguié
Jul 18, 2019·Environmental Health Perspectives·Véronique GayrardNicole Picard-Hagen
Nov 26, 2015·Journal of Veterinary Pharmacology and Therapeutics·J E RiviereJ Mochel
Aug 18, 2020·Environment International·Alan F SassoLinda S Birnbaum

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