Allomyrina dichotoma (Arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet

Nutrients
Young-Il YoonEun-Young Yun

Abstract

To clarify the anti-obesity effect of Allomyrina dichotoma larvae (ADL), we previously reported that ADL block adipocyte differentiation on 3T3-L1 cell lines through downregulation of transcription factors, such as peroxisome proliferator-activated receptor-γ (PPARG) and CCAAT/enhancer binding protein-α (CEBPA). In this study, we tested whether ADL prevent obesity in mice fed a high-fat diet (HFD) and further investigated the mechanism underlying the effects of ADL. All mice were maintained on a normal-fat diet (NFD) for 1 week and then assigned to one of five treatment groups: (1) NFD; (2) HFD; (3) HFD and 100 mg·kg(-1)·day(-1) ADL; (4) HFD and 3000 mg·kg(-1)·day(-1) ADL; or (5) HFD and 3000 mg·kg(-1)·day(-1) yerba mate (Ilex paraguariensis, positive control). ADL and yerba mate were administered orally daily. Mice were fed experimental diets and body weight was monitored weekly for 6 weeks. Our results indicated that ADL reduced body weight gain, organ weight and adipose tissue volume in a dose-dependent manner. Body weight gain was approximately 22.4% lower compared to mice fed only HFD, but the difference did not reach the level of statistical significance. Real-time polymerase chain reaction (PCR) analysis revealed that ge...Continue Reading

References

Mar 27, 1996·Biochemical and Biophysical Research Communications·A MiyanoshitaM Yamakawa
Nov 1, 1996·Cell·B M Spiegelman, J S Flier
Jul 23, 1998·Physiological Reviews·F M GregoireH S Sul
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Jan 7, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V Mohamed-AliS W Coppack
Aug 10, 2000·Fitoterapia·C O Moro, G Basile
Feb 24, 2001·Nature·C M SteppanM A Lazar
Nov 8, 2003·Diabetologia·M Fasshauer, R Paschke
Apr 16, 2004·Seminars in Liver Disease·Elizabeth M Brunt
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Karl G HofbauerOlivier Boss
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Dec 16, 2006·The Journal of Endocrinology·Cid PitomboLício A Velloso
Feb 3, 2007·Journal of Human Hypertension·M J Brookes, B T Cooper
Feb 15, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F LeiL J Du
Mar 14, 2007·Journal of Dermatological Science·Kazumoto KatagiriYutaka Hatano
May 23, 2008·The Journal of Nutritional Biochemistry·Srujana RayalamClifton A Baile
May 16, 2009·Phytotherapy Research : PTR·Mi-Ja Kim, Hye Kyung Kim
Jan 11, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Young-Sil LeeJe-Tae Woo
May 28, 2011·Trends in Immunology·Elise DalmasMichèle Guerre-Millo
Oct 2, 2012·Annual Review of Entomology·Arnold van Huis
Oct 24, 2012·Journal of Ethnopharmacology·Pedro Ernesto de ResendeGeorge González Ortega
Mar 9, 2013·Molecular Nutrition & Food Research·Birgit A Rumpold, Oliver K Schlüter
Jan 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Wook LimHocheol Kim
Jan 29, 2014·Preventive Nutrition and Food Science·Kumju YounMira Jun

❮ Previous
Next ❯

Citations

Feb 26, 2016·The Proceedings of the Nutrition Society·Arnold van Huis
May 27, 2017·Journal of the American College of Nutrition·Jinhui YuYingjie Wu
Mar 23, 2017·Obesity Research & Clinical Practice·Hong-Bo XiaoXiang-Yang Lu
Mar 30, 2018·The American Journal of Chinese Medicine·Jongwan KimIl Soo Moon
May 23, 2018·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Seung-Whan KimO-Yu Kwon
May 10, 2020·Journal of Medicinal Food·Joo Young LeeSungwook Chae
Jun 5, 2016·Asian Pacific Journal of Tropical Medicine·Hyeon-Jeong KimMyung-Haing Cho
Dec 18, 2020·Frontiers in Nutrition·Xiuqin FanKemin Qi
Feb 27, 2021·Biomolecules & Therapeutics·Stephen T DeyrupSiu Wah Wong-Deyrup
Jul 20, 2021·Frontiers in Nutrition·Beatriz A Acosta-EstradaCeleste C Ibarra-Herrera
Sep 3, 2021·Food Science and Biotechnology·Jae Hoon LeeYun-Sang Choi

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Beacon Designer
PREMIER
R
IMT
- Solution Lite

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.