Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways

Nutrients
Jongwan KimMinchul Seo

Abstract

Recent evidence has suggested that the Korean horn beetle (Allomyrina dichotoma) has anti-hepatofibrotic, anti-neoplastic, and antibiotic effects and is recognized as a traditional medicine. In our previous works, Allomyrina dichotoma larvae (ADL) inhibited differentiation of adipocytes both in vitro and in vivo. However, the anorexigenic and endoplasmic reticulum(ER) stress-reducing effects of ADL in obesity has not been examined. In this study, we investigated the anorexigenic and ER stress-reducing effects of ADL in the hypothalamus of diet-induced obese (DIO) mice. Intracerebroventricular (ICV) administration of ethanol extract of ADL (ADE) suggested that an antagonizing effect on ghrelin-induced feeding behavior through the mTOR and MAPK signaling pathways. Especially, ADE resulted in strong reduction of ER stress both in vitro and in vivo. These findings strongly suggest that ADE and its constituent bioactive compounds are available and valuable to use for treatment of various diseases driven by prolonged ER stress.

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Citations

Mar 30, 2018·The American Journal of Chinese Medicine·Jongwan KimIl Soo Moon
Feb 20, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Arnold van Huis
Nov 18, 2020·International Journal of Molecular Sciences·Sung Mun BaeEun-Kyung Kim

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Methods Mentioned

BETA
protein assay
electrophoresis
PCR

Software Mentioned

SPSS

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