PMID: 8448585Feb 1, 1993Paper

Allopurinol and amlodipine improve coronary vasodilatation after myocardial ischaemia and reperfusion in anaesthetized dogs

British Journal of Pharmacology
C G SobeyO L Woodman

Abstract

1. We have assessed the effect of allopurinol, amlodipine and propranolol pretreatment on both endothelium-dependent and endothelium-independent coronary vasodilatation in vivo, by comparing pre-ischaemic responses with those measured after 60 min of coronary artery occlusion and 30 min of reperfusion in anaesthetized dogs. 2. In 15 untreated dogs ischaemia and reperfusion attenuated the increases in coronary blood flow produced by either acetylcholine (0.01-0.05 micrograms kg-1, i.a.) or glyceryl trinitrate (0.05-0.2 micrograms kg-1, i.a.), to an average of 39 +/- 4% and 42 +/- 5% of the pre-ischaemic control response, respectively (both P < 0.05). 3. In 5 dogs treated with allopurinol (25 mg kg-1, orally, 24 h previously, plus 50 mg kg-1, i.v., 5 min before occlusion), the increases in coronary blood flow after ischaemia and reperfusion (acetylcholine: 78 +/- 12%, glyceryl trinitrate: 60 +/- 3% of pre-ischaemic response) were significantly larger than post-ischaemic responses in untreated dogs (both P < 0.05). 4. Similarly, amlodipine treatment (3 micrograms kg-1 min-1, i.v., starting 90 min before occlusion) in 5 dogs improved post-ischaemic increases in blood flow (acetylcholine: 58.5%, glyceryl trinitrate: 66 +/- 6% of pre...Continue Reading

References

Nov 20, 1990·The American Journal of Cardiology·R A Kloner, K Przyklenk
Nov 1, 1990·Circulation Research·J VanhaeckeH De Geest
Nov 7, 1989·The American Journal of Cardiology·P T HoffB R Lucchesi
Jan 1, 1988·European Journal of Clinical Pharmacology·P L CapecchiT Di Perri
Oct 15, 1985·Biochemical Pharmacology·H P JonesJ M McCord
Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings

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Citations

Dec 1, 1993·Trends in Pharmacological Sciences·C G Sobey, O L Woodman
Jun 27, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Monika AngdinJarle Vaage
Mar 6, 1998·International Journal of Cardiology·O L WoodmanC G Sobey

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