Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy

The Cochrane Database of Systematic Reviews
Tejasvi Chaudhari, William McGuire

Abstract

Delayed neuronal death following a perinatal hypoxic insult is due partly to xanthine oxidase-mediated production of cytotoxic free radicals. Evidence exists that allopurinol, a xanthine-oxidase inhibitor, reduces delayed cell death in animal models of perinatal asphyxia and in human patients with other forms of organ reperfusion injury. To determine the effect of allopurinol on mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. The standard search strategy of the Cochrane Neonatal Review Group was used. This included searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 4, 2007), MEDLINE (1966 - December 2007), EMBASE (1980 - December 2007), conference proceedings, and previous reviews. Randomised or quasi-randomised controlled trials that compared allopurinol administration vs. placebo or no drug in newborn infants with suspected hypoxic-ischaemic encephalopathy. The standard methods of the Cochrane Neonatal Review Group were used, with separate evaluation of trial quality and data extraction by two authors. Data were synthesised using a fixed effects model and reported using typical relative risk, typical risk difference and weighted mean...Continue Reading

Citations

Sep 8, 2012·Neurocritical Care·Alexis A TopjianDavid S Warner
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zoya V NiatsetskayaVadim S Ten
Dec 16, 2016·International Journal of Molecular Sciences·Mingyi ZhaoXiao-Kang Li
Jun 1, 2011·The EPMA Journal·Paola MoralesEdgardo Rojas-Mancilla
Feb 28, 2009·Eye·J M DurnianA Chandna
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Tejasvi Chaudhari, William McGuire
Nov 20, 2012·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anne Lee Solevåg, Britt Nakstad
Feb 13, 2020·F1000Research·Samata Singhi, Michael Johnston
Jun 3, 2011·Critical Care Nurse·Nevart Chirinian, Nancy Mann

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