PMID: 8453174Mar 1, 1993Paper

Allopurinol hypersensitivity syndrome: a review

The Annals of Pharmacotherapy
F Arellano, J A Sacristán

Abstract

To review the pathophysiology, pathology, and clinical findings of allopurinol hypersensitivity syndrome (AHS), an infrequent but life-threatening adverse effect of allopurinol therapy. A MEDLINE search (key terms hepatitis, interstitial nephritis, severe hypersensitivity, severe toxicity, vasculitis, toxic epidermal necrolysis, Lyell's syndrome, erythema multiforme, and Stevens-Johnson syndrome) was used to identify cases reported in the literature through the end of 1990. All cases evaluated met Singer and Wallace's diagnostic criteria for AHS. We extracted data from 101 cases of AHS reported in the literature. The following information, when available, was analyzed: (1) patient data (age, gender, medical history), (2) treatment data (daily dosage of allopurinol, duration of treatment, indications, concomitant medications, and (3) adverse-event data. Patients were mostly middle-aged men with hypertension and/or renal failure receiving excessive doses of allopurinol primarily for asymptomatic hyperuricemia. Cutaneous rash and fever were the most common clinical findings. Although the pathophysiologic pathway leading to the development of AHS is unknown, it probably involves an immunologic mechanism following allopurinol accumu...Continue Reading

References

Oct 23, 1976·Lancet·R R BaileyK L Lynn
Feb 4, 1978·Lancet·H C Korting, R Lesch
Sep 1, 1976·Annals of Internal Medicine·O LockardW Irvin
Dec 1, 1976·Australian and New Zealand Journal of Medicine·R A McMenaminP W Craswell
Oct 1, 1977·Australian and New Zealand Journal of Medicine·H L ChanO T Khoo
Nov 1, 1979·Southern Medical Journal·P G Lang
Oct 1, 1979·Journal of the American Academy of Dermatology·G P Lupton, R B Odom
Apr 14, 1979·British Medical Journal·M W McKendrick, A M Geddes
May 20, 1978·British Medical Journal·A MedlineE M Sellers
Feb 1, 1977·Annals of Internal Medicine·D R GelbartL F Fajardo
Aug 1, 1977·Archives of Ophthalmology·T O BennettS Sahgal
Nov 1, 1977·Arthritis and Rheumatism·S K ChawlaW A D'Angelo
Aug 1, 1976·The American Journal of Medicine·P D Utsinger, W J Young
Sep 1, 1976·The American Journal of Digestive Diseases·C R EspirituJ Lubin
Sep 1, 1989·International Journal of Dermatology·L RenfroL A Daman
Aug 23, 1986·Lancet·S Sherlock
Feb 21, 1987·Lancet·M M ElseviersG G De Backer
Nov 1, 1987·Annals of the Rheumatic Diseases·M G Ridley, J A Mathews
Aug 1, 1987·Annals of the Rheumatic Diseases·J UnsworthD T Beswick
Dec 1, 1987·British Journal of Rheumatology·B T EmmersonD B Thomson
Oct 1, 1986·The American Journal of the Medical Sciences·K R Hande
Jun 29, 1985·British Medical Journal·J Auböck, P Fritsch
Jan 1, 1986·Gastroenterology·M VanderstigelJ L Portos
Jan 1, 1986·Arthritis and Rheumatism·J Z Singer, S L Wallace
Jun 1, 1985·Arthritis and Rheumatism·E Webster, R S Panush
Jun 1, 1985·Drug Intelligence & Clinical Pharmacy·T Ohsawa, M Ohtsubo
Jun 1, 1980·Annals of Internal Medicine·B S Mitchell, W N Kelley
Mar 1, 1984·International Journal of Dermatology·M DanS Shibolet
Jan 1, 1981·American Journal of Nephrology·M GrussendorfE Ritz
Jun 1, 1981·Annals of the Rheumatic Diseases·G T McInnesH Jick
Nov 1, 1981·Annals of Internal Medicine·F H Al-KawasK G Ishak

❮ Previous
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Citations

Feb 24, 2001·Arthritis and Rheumatism·A G FamT W Paton
Aug 9, 2002·European Journal of Heart Failure·Lukas E SpiekerGeorg Noll
Dec 9, 2004·Pharmacotherapy·Kerry Wilbur, Mark Makowsky
Apr 22, 2008·Internal Medicine Journal·Y ChungR O Day
May 11, 2010·Medizinische Klinik·Sören LaurischL Christian Napp
Jun 1, 2010·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Neila FathallahKamel Bouraoui
Jul 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·David S Goldfarb
Oct 25, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·L AtzoriN Aste
Aug 29, 2013·International Journal of Rheumatic Diseases·Siaw Ing Yeo
Apr 24, 2014·Clinical and Molecular Hepatology·Hyung Gyu ChoiChul Ju Han
Jun 16, 2015·Expert Opinion on Investigational Drugs·Hania Shahid, Jasvinder A Singh
Aug 7, 2016·Therapeutic Advances in Musculoskeletal Disease·Sebastian E Sattui, Angelo L Gaffo
Mar 4, 2017·Therapeutic Advances in Musculoskeletal Disease·Arabella Waller, Kelsey M Jordan
Jan 18, 2017·Expert Opinion on Drug Safety·Naomi Schlesinger
Feb 16, 2006·The Annals of Pharmacotherapy·Marsha A RaebelRichard Platt
Nov 2, 2005·Expert Opinion on Pharmacotherapy·Gregory Choy
Aug 6, 2009·Current Opinion in Nephrology and Hypertension·Daniel I Feig
Mar 28, 2008·The Korean Journal of Hepatology·Jae Young YoonYoung Min Park
Jul 17, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C-C ChiouW-H Chung
Jan 1, 2010·International Journal of Emergency Medicine·Fabrizio Elia, Franco Aprà
Oct 7, 2009·Pediatric Dermatology·Ashvin K Dewan, Ricardo A Quinonez
Dec 6, 2011·International Journal of Immunogenetics·T Profaizer, D Eckels
Nov 23, 2013·Journal of Food Science·Makoto KondoTsuyoshi Watanabe
Feb 26, 2013·Journal of Clinical Pharmacology·Hee Jung RyuEun Bong Lee
May 8, 2014·Applied Biochemistry and Biotechnology·Neha Kapoor, Sanjai Saxena
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Jean H TayarMaria E Suarez-Almazor
Aug 20, 2014·Nature Reviews. Rheumatology·Lisa Stamp, Nicola Dalbeth
Sep 1, 2010·Personalized Medicine·Mandvi BharadwajLyudmila Kostenko
Apr 14, 2018·Journal of Immunology Research·Chun-Bing ChenWen-Hung Chung

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