Allopurinol-induced melanism in the tiger salamander (Ambystoma tigrinum nebulosum)

The Journal of Experimental Zoology
S K Frost, J T Bagnara

Abstract

The enzyme, xanthine dehydrogenase (XDH), has been examined in Ambystoma tigrinum nebulosum with respect to its role in pigmentation. It now seems probable that the melanoid gene (m) either codes directly for XDH or is somehow intimately connected with the normal function of this enzyme. Inhibition of XDH using the drug, allopurinol, results in animals which appear to be phenocopies of melanoid mutants as described for the Mexican axolotl (Ambystoma mexicanum). The effects of allopurinol in terms of specific pigmentary alterations were examined, and a new method for analyzing heterogeneous extracts of skin pigments (e.g., purines and pteridines) is presented. The significance of the link between XDH and melanism is discussed with emphasis on possible mechanisms of pigment induction and general applicability to biological systems.

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Citations

Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T A Lyerla, P C Fournier
Nov 7, 2000·Journal of Insect Physiology· von Dungern P, H Briegel
Apr 2, 1998·Pigment Cell Research·G Thibaudeau, S Holder
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Jan 26, 2007·Pigment Cell Research·Joseph T BagnaraRoyozo Fujii
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May 1, 1989·Pigment Cell Research·S K FrostM K Carson
Feb 1, 1984·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·J B Armstrong

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