PMID: 6968813Nov 1, 1980Paper

Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors

The Journal of Experimental Medicine
C HardtH Wagner

Abstract

If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed Il-2, upon antigenic stimulation, PNA+ Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA- Lyt 23 cytotoxic effector cells. Along the differentiation pathway from Lyt 123 leads to 23 effector cells, cytolytic activity is carried out by T cells that still express the Lyt 123 phenotype. The data establish that Lyt 23 CTL are produced by differentiation from antecedent Lyt 123 cells.

References

Oct 1, 1976·The Journal of Experimental Medicine·H ShikuH F Oettgen
Sep 1, 1978·The Journal of Experimental Medicine·F H Bach, B J Alter
Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P J WettsteinJ A Frelinger
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Aug 1, 1974·European Journal of Immunology·G M Shearer
Mar 1, 1980·The Journal of Experimental Medicine·F W ShenS P Cort

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Citations

Mar 1, 1983·Veterinary Immunology and Immunopathology·D E Onions
Jan 1, 1982·International Journal of Immunopharmacology·I M Orme, F L Shand
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·A Raedler, S Schreiber
Jan 1, 1981·Immunological Reviews·R Finberg, B Benacerraf
Sep 1, 1982·Immunology Today·R J Hodes
Jan 1, 1989·International Journal of Immunopharmacology·S G VolsenK Miller

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