PMID: 6966311Apr 1, 1980Paper

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines

The Journal of Experimental Medicine
A L Glasebrook, F W Fitch

Abstract

Several T cell clones have been derived by limiting dilution of secondary mixed leukocyte culture cells stimulated by H-2- and M locus (Mls)-disparate spleen cells. When examined for the expression of cytolytic activity and the ability to proliferate, these cell clones can be classified into two major categories. One type of cell is noncytolytic; when cultured with irradiated spleen cells, such clones proliferate in response to Mls determinants. Some, but not all, of these clones express Lyt-1 alloantigens. The other type of cell is cytolytic; these clones do not proliferate when cultured with irradiated allogeneic spleen cells unless supernatant fluid (SF) is added. These cytolytic clones express Lyt-2 alloantigens. Some cytolytic clones are specific for H-2Kd and others for H-2Dd alloantigens. Still other cytolytic cell clones exhibit cross-reactive lysis of different H-2-bearing tumor and Con A blast target cells. Noncytolytic T cell clones, when stimulated by Mls antigens, were examined for their ability to promote proliferation of cytolytic T cell clones. All of the noncytolytic cell clones tested were able to promote proliferation of cytolytic cell clones with the concomitant expression of cytolytic activity directed towa...Continue Reading

References

Jan 1, 1977·Immunological Reviews·F H BachM L Bach
Jul 14, 1977·Nature·S Gillis, K A Smith
Feb 1, 1978·European Journal of Immunology·M UotilaJ Gordon
Jun 23, 1977·Nature·R A GoldsbyL A Herzenberg
Jan 1, 1979·The Journal of Experimental Medicine·P E BakerK A Smith
Jan 1, 1979·Immunological Reviews·T J McKearnF P Stuart
May 24, 1974·Nature·H von Boehmer, J Sprent
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

❮ Previous
Next ❯

Citations

Feb 1, 1992·Journal of Neuroscience Research·J A CohenM B Prystowsky
Dec 1, 1992·Journal of Neuroscience Research·M AraiJ A Cohen
Jan 1, 1982·Immunogenetics·B Jones, C A Janeway
Jan 1, 1988·Immunogenetics·R E Click, A Adelmann
Jan 1, 1989·Immunogenetics·R E Click, A Adelmann
Nov 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·A A Pimenov, B D Brondz
Jan 1, 1992·Biotherapy·D W Lancki, F W Fitch
Jul 30, 1982·Journal of Immunological Methods·W Haas, H Von Boehmer
Feb 28, 1985·Journal of Immunological Methods·K A Wall, F W Fitch
Apr 1, 1984·Cancer Genetics and Cytogenetics·M CianfrigliaM Nabholz
Nov 1, 1983·Human Immunology·N ReinsmoenF H Bach
Jan 1, 1984·Human Immunology·R B Effros, R L Walford
Nov 1, 1984·Human Immunology·N OhtaF H Bach
Jan 1, 1987·Experimental Gerontology·R B Effros, R L Walford
Jan 1, 1989·Experimental Gerontology·N L PerilloR B Effros
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C S ReissS J Burakoff
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D M KranzH N Eisen
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M V SitkovskyH N Eisen
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C PhilippsH Schreiber
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D E SabathM B Prystowsky
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonS M Weissman
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K A WallA D Elbein
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B S Kwon, S M Weissman
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K YuiM I Greene
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E D Cahir McFarlandM L Thomas
Nov 1, 1980·The Journal of Experimental Medicine·S ShimizuR T Smith
Mar 1, 1981·The Journal of Experimental Medicine·G DennertS Yamagata
Mar 1, 1981·The Journal of Experimental Medicine·D P DialynasF W Fitch
Aug 1, 1981·The Journal of Experimental Medicine·H R SnodgrassD B Wilson
Apr 1, 1982·The Journal of Experimental Medicine·J R KleinM J Bevan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.