Alloreactivity of natural killer cells in allogeneic liver transplantation

Transplantation
M OertelF Berr

Abstract

The cytolytic attack of natural killer (NK) cells is blocked by recognition of the idiotypic phenotype of certain polymorphisms in HLA class I molecules, specifically by HLA-C alleles (Asn77, Lys80 or Ser77, Asn80) or HLA-Bw4 allotypes. Because liver allograft rejection is associated closer with mismatch in HLA class I than class II, we investigated the role of NK cells in acute hepatic allograft rejection in vivo/in vitro. The HLA pattern was typed with serological and polymerase chain reaction (PCR) techniques. In 31 liver transplantations, mononuclear cells from donor spleen and peripheral blood of recipients (before/after transplantation) were cultured in mixed lymphocyte cultures (MLC). MLC-derived effector cells were analyzed by flow cytometry and tested in 51Cr-release assays. Patients with NK allospecific constellations tended to have higher numbers of NK cells in peripheral blood during the first 4 weeks after transplantation, and patients' lymphocytes stimulated with donor cells had a significantly higher cytotoxic activity on days 14 and 21 compared with patients without NK allospecificity. However, acute rejection occurred with similar frequency in both groups (31% with allospecific constellations vs. 40% without). ...Continue Reading

References

Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Feb 22, 1990·The New England Journal of Medicine·A M KrenskyP Parham
Dec 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G B KlintmalmG W Tillery
Jan 1, 1988·The Journal of Clinical Investigation·J H KehrlW C Greene
Dec 1, 1988·The Journal of Experimental Medicine·E CicconeL Moretta
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M TsudoT A Waldmann
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P DonaldsonR Williams
Jan 1, 1996·Annual Review of Immunology·A MorettaL Moretta
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Feb 1, 1997·Transplantation Proceedings·N RayesP Neuhaus
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·A CambiaggiE Vivier
Jun 19, 1998·The New England Journal of Medicine·M H Sayegh, L A Turka
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerK M Detre
Mar 19, 1999·Immunology Today·A W Thomson, L Lu

❮ Previous
Next ❯

Citations

Jul 17, 2004·Transplantation·Neil T Young
Mar 30, 2006·Transplantation·William H KitchensJoren C Madsen
Dec 16, 2010·Current Opinion in Organ Transplantation·Gilles BenichouJoren C Madsen
Mar 18, 2011·Journal of Innate Immunity·Jean Villard
Feb 1, 2007·Current Opinion in Organ Transplantation·Maria-Luisa Alegre, Megan E McNerney
Aug 14, 2009·Expert Review of Gastroenterology & Hepatology·Alejandro Espadas de AriasFrancesca Poli
Jan 9, 2007·Human Immunology·Maria R Moya-QuilesUNKNOWN Spanish Group of Transplant Immunology and Immunotolerance (G03/104)
Mar 6, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maria Rosa Moya-QuilesMaría Rocío Alvarez-López
Jun 6, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D C Jones, N T Young
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Taketoshi SuehiroHiroyuki Kuwano
Aug 2, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R HanvesakulD Briggs
Mar 28, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alejandro Espadas de AriasFrancesca Poli
Jun 16, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Viviana MorosoJaap Kwekkeboom
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W van der Touw, J S Bromberg
Nov 7, 2015·Journal of Immunology Research·Priscila de Matos SilvaPatricia Ucelli Simioni
Dec 13, 2006·Transplant Immunology·María R López-AlvarezAlfredo Minguela
Dec 13, 2006·Transplant Immunology·Carlos Vilches, Peter Parham
Mar 31, 2006·Human Immunology·Amal BisharaRifaat Safadi
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian XuAlbrecht Wendel
Aug 24, 2017·Pediatric Transplantation·Keita ShimataYukihiro Inomata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Human Immunology
María R Moya-QuilesSpanish Group of Transplant Immunology and Immunotolerance (G03/104)
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
María R Moya-QuilesM R Alvarez-López
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M E McNerneyM-L Alegre
© 2021 Meta ULC. All rights reserved