Allostatic Load Biomarker Associations with Depressive Symptoms Vary among US Black and White Women and Men

Healthcare
Ganga S BeySharina D Person

Abstract

The prevalence and severity of depression differ in women and men and across racial groups. Psychosocial factors such as chronic stress have been proposed as contributors, but causes of this variation are not fully understood. Allostatic load, a measure of the physiological burden of chronic stress, is known to be associated with depression. Using data from the National Health and Nutrition Examination Survey 2005⁻2010, we examined the associations of nine allostatic load biomarkers with depression among US black and white adults aged 18⁻64 years (n = 6431). Depressive symptoms were assessed using the Patient Health Questionaire-9; logistic models estimated adjusted odds of depression based on allostatic load biomarkers. High-risk levels of c-reactive protein were significantly associated with increased odds of depression among white women (adjusted odds ratio (aOR) = 1.7, 95% CI: 1.1⁻2.5) and men (aOR = 1.8, 95% CI: 1.1⁻2.8) but not black women (aOR = 0.8, 95% CI: 0.6⁻1.1) or men (aOR = 0.9, 95% CI: 0.5⁻1.5). Among black men, hypertension (aOR = 1.7, 95% CI: 1.1⁻2.7) and adverse serum albumin levels (aOR = 1.7, 95% CI: 1.0⁻2.9) predicted depression, while high total cholesterol was associated with depression among black women ...Continue Reading

References

Jan 1, 1987·Social Science & Medicine·L K SussmanF Earls
Feb 15, 1973·The New England Journal of Medicine·A Lazare
Oct 1, 1996·American Journal of Public Health·N Krieger, S Sidney
Jul 21, 1999·American Journal of Epidemiology·J S Kaufman, R S Cooper
Nov 26, 1999·Journal of Personality and Social Psychology·S Nolen-HoeksemaC Grayson
Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·M Piccinelli, G Wilkinson
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Wendy M TroxelKim Sutton-Tyrrell
Nov 6, 2003·American Journal of Public Health·Dorothy D DunlopRowland W Chang
Mar 2, 2005·Nature Reviews. Immunology·Ronald Glaser, Janice K Kiecolt-Glaser
May 26, 2005·American Journal of Public Health·Stephanie A RioloCheryl A King
Aug 2, 2005·Journal of the American College of Cardiology·Amit KheraJames A de Lemos
Dec 29, 2005·American Journal of Public Health·Arline T GeronimusJohn Bound
Jul 1, 2006·Journal of General Internal Medicine·Frederick Y HuangRobert L Spitzer
May 7, 2009·Brain, Behavior, and Immunity·Jesse C StewartThomas W Kamarck
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Erica P Gunderson
Feb 16, 2010·Qualitative Health Research·Cheryl L Woods-Giscombé
Mar 26, 2010·Depression and Anxiety·Monica UddinSandro Galea
Sep 18, 2010·Current Psychiatry Reports·Falk W Lohoff
Sep 20, 2011·Current Psychiatry Reports·Charles L Raison, Andrew H Miller
Mar 3, 2012·Stress and Health : Journal of the International Society for the Investigation of Stress·Peter G Mezo, Robyn M Baker
May 11, 2013·Journal of Women's Health·Margaret T HickenJames S Jackson
Jun 5, 2013·Social Psychiatry and Psychiatric Epidemiology·David M BarnesLisa M Bates
Jun 15, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Bethany K Wexler Rainisch, Dawn M Upchurch
Jul 12, 2013·JAMA : the Journal of the American Medical Association·Christopher J L MurrayUNKNOWN U.S. Burden of Disease Collaborators
Jan 17, 2014·Physiology & Behavior·Roni W KobroslyJan Moynihan
Jan 21, 2015·Cultural Diversity & Ethnic Minority Psychology·Natalie N Watson, Carla D Hunter
Nov 19, 2015·JAMA Psychiatry·Markus JokelaMika Kivimäki
Apr 6, 2016·Frontiers in Public Health·Shervin Assari, Maryam Moghani Lankarani
Jun 9, 2016·Journal of Racial and Ethnic Health Disparities·Shervin Assari, Maryam Moghani Lankarani
Jun 9, 2016·Obesity Science & Practice·Lauren R PowellStephenie C Lemon
Jun 14, 2016·Journal of Racial and Ethnic Health Disparities·Zhili ShaoRahn Kennedy Bailey
Jan 23, 2018·The American Journal of Orthopsychiatry·Ganga S BeySharina D Person
Jul 11, 2018·Journal of Racial and Ethnic Health Disparities·Ganga S BeySharina D Person

❮ Previous
Next ❯

Citations

Jan 26, 2021·Psychoneuroendocrinology·Jay O'Shields, Jeremy J Gibbs

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.