Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State

Basic & Clinical Pharmacology & Toxicology
Danuta JantasWładysław Lasoń

Abstract

The participation of group III metabotropic glutamate receptors (mGluRs) in cancer growth and progression is still an understudied issue. Based on our recent data on high expression of mGluR8 in human neuroblastoma SH-SY5Y cells, in this study, we evaluated the effect of an mGluR8-specific positive allosteric modulator (PAM: AZ12216052) and orthosteric agonist [(S)-3,4-DCPG ((S)-3,4-dicarboxyphenylglycine)] on chemotherapeutic (doxorubicin, irinotecan or cisplatin)-evoked cell damage in undifferentiated (UN-) and retinoic acid-differentiated (RA-) SH-SY5Y cells. The data showed that AZ12216052 as well as a group III mGluR antagonist (UBP1112) but not (S)-3,4-DCPG partially inhibited the cell damage evoked by doxorubicin, irinotecan or cisplatin in UN-SH-SY5Y cells. In RA-SH-SY5Y, we observed only a modest protective effect of mGluR8 PAM. In contrast, both types of mGluR8 activators significantly enhanced toxic effects of doxorubicin and irinotecan in RA-SH-SY5Y cells. These data suggest that in undifferentiated neuroblastoma malignant cells, some mGluR8 modulators can decrease cytotoxic effects of chemotherapeutics which exclude them from the group of putative anticancer agents. On the other hand, in SH-SY5Y cells differentiate...Continue Reading

References

Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·S Nakanishi, M Masu
Sep 18, 2002·Biochemical Pharmacology·Wojciech RzeskiLechoslaw Turski
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Byong Chul YooJae-Gahb Park
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hee Jin ChangJae-Gahb Park
Jul 26, 2005·Neuropharmacology·Yarí E MarínSuzie Chen
Nov 25, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Georgia Papaioannou, Kieran McHugh
Apr 1, 2006·Pharmacology & Therapeutics·Gurpreet K Dhami, Stephen S G Ferguson
Jul 19, 2006·Cell and Tissue Research·Francesco Ferraguti, Ryuichi Shigemoto
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luisa IacovelliFerdinando Nicoletti
Apr 17, 2007·Trends in Pharmacological Sciences·Ferdinando NicolettiDaniela Melchiorri
Aug 1, 2007·Journal of Neuroscience Research·Chul Hoon KimKatherine W Roche
Apr 26, 2008·Pigment Cell & Melanoma Research·Seung-Shick ShinSuzie Chen
Jun 17, 2008·Neuropharmacology·Seung-Shick ShinSuzie Chen
Jun 16, 2009·Histochemistry and Cell Biology·Andrzej StepulakChrysanthy Ikonomidou
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Colleen M Niswender, P Jeffrey Conn
Apr 14, 2010·Behavioural Brain Research·Robert M DuvoisinJacob Raber
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rochelle BagatellSusan L Cohn
Mar 9, 2011·Behavioural Brain Research·Robert M DuvoisinJacob Raber
Jun 18, 2011·Breast Cancer Research and Treatment·Cecilia L SpeyerDavid H Gorski
Jun 5, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Jessica Teh, Suzie Chen
Jul 17, 2012·Molecular Cancer Research : MCR·Janet Wangari-TalbotSuzie Chen
Aug 3, 2013·Translational Oncology·Kristoffer von StedingkHåkan Axelson
Aug 29, 2013·International Journal of Biological Sciences·Stacey S Willard, Shahriar Koochekpour
Mar 13, 2014·Journal of Neural Transmission·Andrzej StepulakChrysanthy Ikonomidou
Dec 23, 2014·Current Opinion in Pharmacology·Philippe Rondard, Jean-Philippe Pin
Aug 21, 2015·Biochemical Pharmacology·Tara GelbJarda T Wroblewski
Feb 21, 2016·Neuropharmacology·Lumeng J YuSuzie Chen
Mar 19, 2016·The International Journal of Biochemistry & Cell Biology·Samarjit Bhattacharyya

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.