Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose

The Journal of Experimental Biology
Agnieszka JendroszekAngela Fago

Abstract

The high blood-O2 affinity of the bar-headed goose (Anser indicus) is an integral component of the biochemical and physiological adaptations that allow this hypoxia-tolerant species to undertake migratory flights over the Himalayas. The high blood-O2 affinity of this species was originally attributed to a single amino acid substitution of the major hemoglobin (Hb) isoform, HbA, which was thought to destabilize the low-affinity T state, thereby shifting the T-R allosteric equilibrium towards the high-affinity R state. Surprisingly, this mechanistic hypothesis has never been addressed using native proteins purified from blood. Here, we report a detailed analysis of O2 equilibria and kinetics of native major HbA and minor HbD isoforms from bar-headed goose and greylag goose (Anser anser), a strictly lowland species, to identify and characterize the mechanistic basis for the adaptive change in Hb function. We find that HbA and HbD of bar-headed goose have consistently higher O2 affinities than those of the greylag goose. The corresponding Hb isoforms of the two species are equally responsive to physiological allosteric cofactors and have similar Bohr effects. Thermodynamic analyses of O2 equilibrium curves according to the two-stat...Continue Reading

References

Nov 1, 1975·Analytical Biochemistry·O W van Assendelft, W G Zijlstra
Feb 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D PetschowC Bauer
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T H JessenG Braunitzer
Sep 1, 1974·Journal of Applied Physiology·J J Jaeger, J J McGrath
Feb 1, 1980·Respiration Physiology·C P Black, S M Tenney
Mar 1, 1996·Nature Structural Biology·S E MylvaganamE D Getzoff
Aug 24, 1999·The Journal of Biological Chemistry·C BonaventuraR D Stevens
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Nov 24, 2004·Respiratory Physiology & Neurobiology·Roy E Weber, Angela Fago
Mar 28, 2006·Respiratory Physiology & Neurobiology·Graham R Scott, William K Milsom
May 11, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Graham R Scott, William K Milsom
Jun 15, 2007·Respiratory Physiology & Neurobiology·Roy E Weber
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lucy A HawkesCharles M Bishop
Jul 15, 2011·The Journal of Experimental Biology·Graham R Scott
Jun 14, 2012·The Journal of Experimental Biology·Signe Helbo, Angela Fago
Sep 11, 2012·The Journal of Biological Chemistry·Michael T GrispoJay F Storz
Nov 3, 2012·Proceedings. Biological Sciences·L A HawkesC M Bishop
Mar 9, 2013·The Journal of Experimental Biology·Jessica U Meir, William K Milsom
May 31, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy E WeberThomas A Gorr
Jun 15, 2013·Science·Chandrasekhar NatarajanJay F Storz
Aug 30, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christian DamsgaardAngela Fago
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joana Projecto-GarciaJay F Storz
Nov 22, 2014·Molecular Biology and Evolution·Danielle M TuftsJay F Storz
Dec 17, 2014·Molecular Biology and Evolution·Juan C OpazoJay F Storz
Mar 3, 2015·Physiology·Graham R ScottWilliam K Milsom
Sep 12, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay F StorzRoy E Weber
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Spencer C GalenChristopher C Witt
Apr 22, 2017·Journal of Applied Physiology·Angela Fago
Nov 4, 2017·Current Opinion in Structural Biology·Jay F Storz

❮ Previous
Next ❯

Citations

Jun 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jay F StorzArlin Stoltzfus
Oct 24, 2019·Biochemical Society Transactions·David CoombesRenwick C J Dobson
Oct 15, 2019·The FEBS Journal·Julia LüdemannThorsten Burmester
Sep 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peng PuQiang Chen
Feb 6, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angela FagoJay F Storz
Sep 17, 2020·The Biochemical Journal·Chandrasekhar NatarajanJay F Storz
Nov 25, 2020·Annual Review of Animal Biosciences·Jay F Storz, Zachary A Cheviron
Mar 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Anthony V SignoreJay F Storz
Apr 21, 2021·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Peng PuQiang Chen
Jul 10, 2021·Frontiers in Genetics·Jay F Storz, Anthony V Signore
Aug 3, 2021·The Journal of Experimental Biology·Naim M BautistaAngela Fago
Oct 28, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naim M BautistaAngela Fago
Dec 17, 2021·The Journal of Experimental Biology·Catherine M IvyGraham R Scott

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Christian DamsgaardAngela Fago
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
A BardgardR E Weber
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Birgitte JensenAngela Fago
© 2022 Meta ULC. All rights reserved