Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors

Experientia
S J Edelstein, J P Changeux

Abstract

A key statement of the 1965 Monod-Wyman-Changeux (MWC) model for allosteric proteins concerns the distinction between the ligand-binding function (Y) and the relevant state function (R). Sequential models predict overlapping behavior of the two functions. In contrast, a straightforward experimental consequence of the MWC model is that for an oligomeric protein the parameters which characterize the two functions should differ significantly. Two situations, where R > Y and the system is hyper-responsive or where R < Y and the system is hypo-responsive, have been encountered. Indeed, the hyper-responsive pattern was first observed for the enzyme aspartate transcarbamoylase, by comparing Y with R monitored by a change in sedimentation. Extensions of the theory to ligand-gated channels led to the suggestion that, on the one hand, hyper-responsive properties also occur with high-affinity mutants. On the other hand, native channels of the acetylcholine neuronal alpha 7 receptor and low-affinity mutants of the glycine receptor can be interpreted in terms of the hypo-responsive pattern. For the ligand-gated channels, whereas R is detected directly by ion flux, ligand binding has rarely been measured and the formation of desensitized sta...Continue Reading

References

Jul 1, 1975·Quarterly Reviews of Biophysics·R G ShulmanS Ogawa
Jan 1, 1975·Annual Review of Biochemistry·S J Edelstein
Nov 1, 1992·Neuroreport·A Devillers-ThiéryD Bertrand
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D BertrandJ P Changeux
Aug 1, 1989·Neuron·L O Trussell, G D Fischbach
May 1, 1989·Quarterly Reviews of Biophysics·M F Perutz
Mar 26, 1971·Nature·S J Edelstein
Sep 5, 1972·Biochemical and Biophysical Research Communications·S J Edelstein
Nov 14, 1966·Journal of Molecular Biology·M M Rubin, J P Changeux
Sep 21, 1984·Science·J P ChangeuxP Chemouilli
Nov 1, 1993·The Journal of Membrane Biology·A Devillers-ThiéryJ P Changeux
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Eigen, R Rigler
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhnoA G Engel
Jan 1, 1995·Annual Review of Physiology·D S McGehee, L W Role
Aug 1, 1993·Trends in Pharmacological Sciences·R J LefkowitzT Costa
Mar 23, 1993·Biochemistry·C RivettiW A Eaton
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L YakelR A North
Mar 15, 1996·Science·G Schatz, B Dobberstein
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·J L GalziJ Changeux
Jun 1, 1957·British Journal of Pharmacology and Chemotherapy·B KATZ, S THESLEFF

❮ Previous
Next ❯

Citations

Jul 5, 2007·European Biophysics Journal : EBJ·Antoine Taly
May 20, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S J EdelsteinJ P Changeux
Oct 23, 1998·Journal of Physiology, Paris·C Léna, J P Changeux
Feb 7, 1998·Current Opinion in Neurobiology·C Léna, J P Changeux
Feb 24, 2011·Journal of Agricultural and Food Chemistry·Motohiro Tomizawa, John E Casida
May 16, 2009·Acta Pharmacologica Sinica·Yong-chang ChangYao Huang
Apr 16, 2005·Annual Review of Pharmacology and Toxicology·William M Atkins
Nov 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Antoine TalyJean-Pierre Changeux
Aug 12, 2010·Pharmaceuticals·Yongchang ChangPaul Whiteaker
Jan 5, 2010·The Journal of Physiology·Alpa Khatri, David S Weiss
Sep 5, 2001·FEBS Letters·V Itier, D Bertrand
Jan 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nurit Degani-KatzavYoav Paas
Oct 23, 2009·British Journal of Pharmacology·Clark A BriggsMurali Gopalakrishnan
Jul 17, 2010·Neuropharmacology·Galya R AbdrakhmanovaF Ivy Carroll
Oct 21, 2016·Nature·Claudio L Morales-PerezRyan E Hibbs
Jul 24, 2013·The Journal of Biological Chemistry·Jean-Pierre Changeux
Oct 23, 1998·Journal of Physiology, Paris·B Buisson, D Bertrand
Jul 4, 1998·Brain Research. Brain Research Reviews·J P ChangeuxM Zoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
J L GalziJ P Changeux
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
S J EdelsteinJ P Changeux
Proceedings of the National Academy of Sciences of the United States of America
J L GalziJ P Changeux
© 2022 Meta ULC. All rights reserved