PMID: 9423578Jan 10, 1998Paper

Allylmercapturic acid as urinary biomarker of human exposure to allyl chloride

Occupational and Environmental Medicine
B M de RooijN P Vermeulen

Abstract

To evaluate the use of urinary mercapturic acids as a biomarker of human exposure to allyl chloride (3-chloropropene) (AC). During three regular shut down periods in a production factory for AC, both types of variables were measured in 136 workers involved in maintenance operations. Potential airborne exposure to AC was measured by personal air monitoring in the breathing zone. In total 205 workshifts were evaluated. During 99 workshifts no respiratory protection equipment was used. Mercapturic acid metabolites were measured in urinary extracts by gas chromatography-mass spectrometry (GC-MS). During 86 work shifts when no respiratory protection was used the air concentrations of AC were below the Dutch eight hour time weighted average (8 h-TWA) occupational exposure limit (OEL) of AC (3 mg/m3), whereas in 13 workshifts the potential exposure, as measured by personal air monitoring, exceeded the OEL (3.3 to 17 mg/m3). With the aid of GC-MS, 3-hydroxypropylmercapturic acid (HPMA) was identified as a minor and allylmercapturic acid (ALMA) as a major metabolite of AC in urine samples from the maintenance workers exposed to AC. The concentrations of ALMA excreted were in a range from < 25 micrograms/l (detection limit) to 3550 micro...Continue Reading

References

Mar 1, 1978·Mutation Research·E C McCoyH S Rosenkranz
Apr 15, 1977·International Archives of Occupational and Environmental Health·F Seutter-BerlageP T Henderson
Jan 1, 1992·Critical Reviews in Toxicology·R T van WelieN J van Sittert
Dec 1, 1991·Regulatory Toxicology and Pharmacology : RTP·D K StevensJ N Blancato
Jul 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G F Phillips, R E Waller
Jan 1, 1991·International Archives of Occupational and Environmental Health·R T van WelieN P Vermeulen
Jan 1, 1991·Chemico-biological Interactions·M Koob, W Dekant
Aug 1, 1989·Journal of Applied Toxicology : JAT·R SandujaP J Boor
Oct 9, 1987·Journal of Chromatography·J Jandke, G Spiteller
Mar 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C M KayeL Young
Feb 1, 1982·Ecotoxicology and Environmental Safety·B Q LuT Chui
Apr 1, 1995·Environmental Health Perspectives·J L PirkleD L Ashley
Mar 1, 1993·Environmental Health Perspectives·N J van SittertH van der Waal
Apr 1, 1993·British Journal of Industrial Medicine·P J BoogaardN J van Sittert
Jan 1, 1996·Archives of Toxicology·B M de RooijN P Vermeulen
Jun 1, 1959·American Industrial Hygiene Association Journal·T R TORKELSONV K ROWE

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Citations

May 11, 2005·International Archives of Occupational and Environmental Health·V Haufroid, D Lison
Feb 2, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L Y SheenS J Tsai
Feb 1, 2003·Environmental Toxicology and Pharmacology·Ron van der OostNico P E Vermeulen
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Luigi PerbelliniAndrea Princivalle
Aug 25, 2001·The British Journal of Nutrition·H VerhagenH Mykkänen
Dec 24, 2004·Critical Reviews in Food Science and Nutrition·Farhath KhanumK R Viswanathan
Oct 24, 2001·Environmental Health Perspectives·F Bianchini, H Vainio
Dec 13, 2005·Neurochemical Research·Qing-Shan WangSu-fang Yu
Apr 2, 2011·Nature Reviews. Drug Discovery·B Kevin ParkThomas A Baillie
Jul 11, 2013·Analytical and Bioanalytical Chemistry·Wolfgang Gries, Gabriele Leng
Jan 5, 2019·Genes & Nutrition·Giulia PraticòLars O Dragsted
Jun 29, 1999·Analytical Chemistry·W M DraperP R Michael

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