Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland

Endocrinology
A SourlaF Labrie

Abstract

To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the pure antiestrogen EM-800 for 12 months. We have also evaluated the effect of estradiol (E2) and dihydrotestosterone constantly released from SILASTIC brand silicon implants as well as medroxyprogesterone acetate released from poly(lactide-co-glycolide) microspheres. While 1-yr OVX resulted in a severe atrophy of the mammary gland, treatment of OVX animals with DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. The addition of FLU to DHEA almost completely prevented the stimulatory effect observed with DHEA alone, whereas addition of the antiestrogen EM-800 had no significant effect on the action of DHEA on the mammary gland. At the doses used, medroxyprogesterone acetate and dihydrotestosterone also stimulated ductal and alveolar development, although to a lesser degree than that achiev...Continue Reading

Citations

Mar 1, 2012·Hormones & Cancer·Ulla SimanainenDavid J Handelsman
Jun 19, 2013·Reproductive Toxicology·Julie BobergChristine Nellemann
Jun 21, 2013·The Journal of Sexual Medicine·Georges PelletierFernand Labrie
Aug 22, 2012·The Journal of Sexual Medicine·Georges PelletierFernand Labrie
Jul 8, 2008·The Journal of Steroid Biochemistry and Molecular Biology·D H AbogheJ St-Amand
Feb 5, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Louise BergerFernand Labrie
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·G PelletierF Labrie
Mar 10, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Qianxing MoNeal G Simon
Jun 28, 2005·The Journal of Steroid Biochemistry and Molecular Biology·L BergerF Labrie
Nov 1, 2012·Toxicologic Pathology·Daniel RudmannUNKNOWN INHAND Mammary, Zymbal's, Preputial, and Clitoral Gland Organ Working Group
Jun 18, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Chambô-FilhoF E L Pereira
Nov 23, 2016·Menopause : the Journal of the North American Menopause Society·Fernand LabrieGeorges Pelletier
May 30, 1998·Journal of the National Cancer Institute·S CouillardF Labrie
May 4, 2012·Toxicologic Pathology·Robert E Chapin, Dianne M Creasy
Jun 8, 2004·Endocrine Reviews·Woraluk SomboonpornUNKNOWN National Health and Medical Research Council
Jul 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fernand Labrie

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