Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity

Obesity Research & Clinical Practice
Kouji NomaguchiTeruo Kawada

Abstract

Lophenol (Lo) and cycloartanol (Cy), minor phytosterols of Aloe vera gel, were previously identified as anti-diabetic compounds, and these compounds also reduced body fat in a type 2 diabetic model animal. In this study, we investigated the effects of Lo and Cy on peroxisome proliferator activated receptors (PPAR) using a luciferase reporter assay. DNA microarray and real-time quantitative RT-PCR (qPCR) analyses were also performed in a diet-induced obesity (DIO) mouse model. The Aloe phytosterols activated PPAR in a dose-dependent manner. The expression levels of many PPAR target genes were changed in the Aloe phytosterol group compared with those in the control high-fat diet (HFD) group. In particular, the expression levels of Fatp1, Acox1, Cpt1, and Hmgcs2 were significantly increased in the Aloe phytosterol group compared with those in the control HFD group; however, the expression level of ApoCIII was significantly decreased in the Aloe phytosterol group. We confirmed that Aloe phytosterols activate PPAR transcription in vitro. In addition, quantitative gene expression analysis in DIO mice suggested that Aloe phytosterols improve fatty acid metabolism in the liver.:

References

Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Dec 1, 1996·Journal of Ethnopharmacology·B VázquezB Escalante
Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
Jan 7, 2000·Journal of Ethnopharmacology·T Reynolds, A C Dweck
May 29, 2000·The Journal of Biological Chemistry·M Guerre-MilloB Staels
Jun 6, 2000·Nature·S KerstenW Wahli
Nov 30, 2000·Biochemical and Biophysical Research Communications·J SakamotoH Sawada
Mar 27, 2001·Phytotherapy Research : PTR·A OkyarN Sütlüpinar
Jun 11, 2002·Annual Review of Nutrition·Frédéric Picard, Johan Auwerx
May 1, 2004·Journal of Medicinal Food·S RajasekaranS Subramanian
Jul 28, 2005·Diabetes·Bart Staels, Jean-Charles Fruchart
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Miyuki TanakaRyuuichi Higuchi
Dec 7, 2007·Biochemical and Biophysical Research Communications·Kayo KuroyanagiTeruo Kawada
Dec 24, 2008·Molecular and Cellular Biochemistry·Gregory G MartinFriedhelm Schroeder
Nov 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S YongchaiyudhaO Chokechaijaroenporn
Nov 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N BunyapraphatsaraO Chokechaijaroenporn

❮ Previous
Next ❯

Citations

Dec 17, 2015·Phytotherapy Research : PTR·Ramesh PothurajuShaik Abdul Hussain
Dec 1, 2015·Obesity Research & Clinical Practice·Martha Elisa Ferreira de AlmeidaRegiane Victória de Barros Fernandes
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Hao HanLiegang Liu
Sep 25, 2016·Plant Foods for Human Nutrition·Rong ShuangLi Wenfang
Oct 8, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam AkaberiSeyed Ahmad Emami
Dec 21, 2016·Photodermatology, Photoimmunology & Photomedicine·Eriko MisawaFukumi Furukawa
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Takeshi ChiharaShigeru Sonoda
Feb 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Takeshi ChiharaFumiaki Abe
Aug 11, 2012·Journal of Nutritional Science and Vitaminology·Eriko MisawaKeiji Iwatsuki
Aug 29, 2019·Phytotherapy Research : PTR·Zahra ShakibHossein Hosseinzadeh
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Rodrigo SalazarDiego Soto-Cabrera
Aug 22, 2020·World Journal of Hepatology·Naruemon KlaikeawPrasong Siriviriyakul
Jun 3, 2021·Medicines·Olubukola Sinbad OlorunnisolaOlumide Samuel Fadahunsi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.