Alogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits

Journal of the American Heart Association
Xiaowei ZhangTong Liu

Abstract

There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model. A total of 90 rabbits were randomized into 3 groups as follows: control group (n=30), alloxan-induced diabetes mellitus group (n=30), and alogliptin-treated (12.5 mg/kg per day for 8 weeks) diabetes mellitus group (n=30). Echocardiographic and hemodynamic assessments were performed in vivo. The serum concentrations of glucagon-like peptide-1, insulin, and inflammatory and oxidative stress markers were measured. Electrophysiological properties of Langendorff-perfused rabbit hearts were assessed. Mitochondrial morphology, respiratory function, membrane potential, and reactive oxygen species generation rate were assessed. The protein expression of transforming growth factor β1, nuclear factor κB p65, and mitochondrial biogenesis-related proteins were measured by Western blot analysis. Diabetic rabbits exhibited left ventricular hypertrophy and left atrial dilation without obvious hemodynamic abnormalities, and all of these changes were attenuated ...Continue Reading

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Citations

Apr 28, 2018·Current Opinion in Cardiology·Kalliopi PafiliNikolaos Papanas
Mar 3, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Apr 13, 2020·Journal of Cellular and Molecular Medicine·Lucia-Doina Popov
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Dec 14, 2018·Experimental and Therapeutic Medicine·Suleyman YesilMustafa Arslan
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Mar 17, 2021·Cardiovascular Research·Martin AguilarSvetlana Reilly
Jun 3, 2021·Journal of Clinical Medicine·Paweł Muszyński, Tomasz A Bonda
May 20, 2021·Oxidative Medicine and Cellular Longevity·Habib YaribeygiAmirhossein Sahebkar
Jun 12, 2021·Heart Rhythm O2·Hailey J JansenRobert A Rose

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Methods Mentioned

BETA
ELISA
protein assay
Fluorescence
electrophoresis
PCR
MDA
coronary artery bypass

Software Mentioned

Image
Pro Plus

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