AlOH3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background

Neuromuscular Disorders : NMD
Francois-Jérôme AuthierR K Gherardi

Abstract

Macrophagic myofasciitis (MMF) is a specific histopathologic lesion involved in the persistence for years of aluminum hydroxide [Al(OH)(3)] at the site of previous intramuscular (i.m.) injection. In order to study mechanisms involved persistence of MMF lesions, we set up an experimental model of MMF-lesion in Sprague-Dawley and Lewis rat, by i.m. injections of 10 microL of an Al(OH)(3)-adjuvanted vaccine. An evaluation carried out over a 12-month period disclosed significant shrinkage of MMF lesions with time. A radioisotopic study did not show significant aluminium uptake by Al(OH)(3)-loaded macrophages. A morphometric approach showed that Lewis rats with Th1-biased immunity had significantly smaller lesions than Sprague-Dawley rats with balanced Th1/Th2 immunity. Concluding, our results indicate that genetic determinatives of cytotoxic T-cell responses could interfere with the clearance process and condition the persistence of vaccine-induced MMF-lesions.

References

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Citations

Oct 1, 2010·Clinical Reviews in Allergy & Immunology·Eitan IsraeliYehuda Shoenfeld
Jan 12, 2012·Lupus·R K Gherardi, F J Authier
Apr 6, 2013·BMC Medicine·Zakir KhanJosette Cadusseau
Mar 12, 2011·Toxicology Letters·Alexander Batista-DuharteErnesto Oviedo-Orta
Aug 11, 2007·Vaccine·Anne-Cécile RimaniolPascal Clayette
Sep 7, 2007·Annals of the New York Academy of Sciences·Aaron Lerner
Feb 24, 2015·Frontiers in Neurology·Romain Kroum GherardiJosette Cadusseau
Dec 17, 2014·Frontiers in Neurology·Muriel RigoletFrançois Jérôme Authier
Sep 15, 2009·Journal of Inorganic Biochemistry·Maryline CouetteFrançois-Jérôme Authier
Oct 7, 2011·Journal of Biomedical Materials Research. Part a·Amit AuroraKathleen A Derwin
Jul 18, 2020·Scientific Reports·Hyunhee KimSung-Hye Park
Feb 23, 2020·Annales pharmaceutiques françaises·L AngrandG Crépeaux
Jun 18, 2019·Best Practice & Research. Clinical Rheumatology·Mehdi Aoun SebaitiFrançois Jérôme Authier
Oct 12, 2020·Journal of Inorganic Biochemistry·Housam EidiChristopher A Shaw

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