Alopecia areata in a rhesus monkey (Macaca mulatta)

Journal of Medical Primatology
B BeardiF-J Kaup

Abstract

A 14-year-old female rhesus monkey (Macaca mulatta) of Chinese origin has been suffering from alopecia universalis since childhood. Recently, the health status of the animal was recorded comprehensively by detailed clinical examination including hematology and serology supplemented by histological and immunohistochemical investigations of skin biopsies and molecular biological techniques to clarify the causes of the persistent hair loss. The hairless gene (hr) nonsense mutation was ruled out by polymerase chain reaction and by sequencing of the corresponding gene. Histological examinations revealed a prominent chronic lymphocytic perifolliculitis and folliculitis affecting anagen stage hair follicles as well as miniaturized hair follicles. Immunohistochemistry using the antibodies CD3, CD20 and CD4 confirmed the diagnosis of a T-cell-mediated autoimmune disease resembling alopecia areata universalis in humans.

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Citations

Nov 10, 2015·The Journal of Investigative Dermatology. Symposium Proceedings·John P SundbergLloyd E King
Jul 1, 2015·Veterinary Dermatology·Pedro J GinelElena Mozos
Apr 30, 2016·American Journal of Primatology·Rose KroekerJulie M Worlein
Jan 20, 2011·Veterinary Pathology·D Y KimD Senter
May 28, 2019·Journal of Medical Primatology·Corrine K LutzMelinda A Novak

Related Concepts

Alopecia Areata
Autoimmune Diseases
Macaca mulatta
Monkey Diseases
Structure of Nail of Toe
Skin
Thyroid Hormones
Leukocyte Differentiation Antigens, Human
Nested Polymerase Chain Reaction
Oligonucleotide Primers

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