Alopecia in association with lamotrigine use: an analysis of individual case safety reports in a global database.

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Maria TengstrandRichard Hill

Abstract

The WHO Programme for International Drug Monitoring, maintained by the Uppsala Monitoring Centre (UMC), has more than 90 member countries contributing individual case safety reports (ICSRs) from their existing national pharmacovigilance systems; these reports are stored in the WHO global ICSR database, VigiBase. A continuous increase of ICSRs of alopecia in suspected connection to lamotrigine use has been observed in VigiBase; however, only limited information has been published on this topic. To examine in greater detail the association between lamotrigine and alopecia by outlining the characteristics of the accumulated reports in VigiBase. An analysis of all reports in VigiBase, up to 1 April 2009, where lamotrigine was suspected of having caused alopecia. Lamotrigine was suspected of being involved in the development of alopecia in 337 patients, reported from 19 countries. The age of the patients ranged between 5 months and 84 years (mean 36 years), with a predominance (58%) of patients <40 years of age. 272 patients were female. In 291 reports, lamotrigine was the only drug suspected by the reporter, and in 112 reports, lamotrigine was the sole reported drug. Commonly co-reported drugs were other antiepileptic drugs. For 21...Continue Reading

References

Mar 1, 1995·International Journal of Dermatology·P I Pillans, D J Woods
Apr 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A TosiF Bardazzi
Aug 11, 1998·European Journal of Clinical Pharmacology·A BateR M De Freitas
Apr 26, 2005·Acta Dermato-venereologica·Annalisa PatriziIria Neri
Aug 1, 2006·The American Journal of Psychiatry·Thomas HillemacherHelge Frieling
Feb 1, 2008·Bulletin of Mathematical Biology·Xingzhou YangLisa J Fauci
Apr 3, 2008·The Journal of Clinical Investigation·Anthony S Fauci

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Citations

May 16, 2013·CNS Drugs·Athanasios Gaitatzis, Josemir W Sander
May 7, 2014·Journal of Pharmacology & Pharmacotherapeutics·Ramakant DixitSunil Mathur
Dec 17, 2014·Epilepsy & Behavior : E&B·B ChenK Detyniecki
Jan 1, 2012·Journal of Central Nervous System Disease·Saima Kayani, Deepa Sirsi
Mar 28, 2017·American Journal of Therapeutics·Marco SolmiGiuseppe Manuli

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