Alpha- and beta-adrenergic receptor polymorphisms in hypertensive and normotensive offspring

Journal of Cardiovascular Medicine
Massimo IacovielloMaria Vittoria Pitzalis

Abstract

The offspring of hypertensive families are characterized by higher arterial blood pressure values and a depressed autonomic control of heart rate. The present study aimed to verify whether these differences are associated with a different genotype distribution of functionally relevant polymorphisms of the alpha- and beta-adrenergic receptor (AR) genes. We selected 109 age- and sex-matched young normotensive subjects with (FH+, n = 56) and without (FH-, n = 53) a family history of hypertension who underwent evaluation of arterial pressure; 24-h electrocardiogram monitoring to assess time-domain parameters of autonomic heart rate control [i.e. mean RR interval (NN), SD of RR intervals (SDNN) and mean square root of the differences of consecutive RR intervals (rMSSD)]; spectral baroreflex sensitivity measurement; and echo-Doppler to assess diastolic function and left ventricular mass. They were also characterized for the following polymorphisms by means of polymerase chain reaction-restriction fragment polymorphism analysis: Arg492Cys in the alpha1a-AR; Del301-303 in the alpha2b-AR; Ser49Gly and Arg389Gly in the beta1-AR; and the 5' leader cistron Arg19Cys, Arg16Gly and Gln27Glu in the beta2-AR. FH+ individuals showed a higher sys...Continue Reading

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Citations

Feb 5, 2010·Autonomic Neuroscience : Basic & Clinical·Sandro SorrentinoStefano Favale
Feb 20, 2014·Autonomic Neuroscience : Basic & Clinical·Guadalupe Hernández-PachecoHéctor Serrano
Dec 3, 2017·Journal of Clinical Laboratory Analysis·Jianlong HanChunzheng Gao
Nov 26, 2014·The Pharmacogenomics Journal·A AdefurinD Kurnik
Jun 15, 2014·Pharmacological Reviews·Andrea Ahles, Stefan Engelhardt

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