Jun 1, 1976

alpha- and beta-adrenergic receptors in regulation of ionic transport in frog cornea

The American Journal of Physiology
R MontoreanoP Cook

Abstract

The effect of catecholamines and adrenergic blocking agents on the transport of Cl- and Na+ of the isolated frog cornea was studied. Cl- transport was stimulated by the three catecholamines tested at 10(-6) to 10(-5) M concentration. The stimulation produced by 10(-6) M epinephrine was partially inhibited by both the alpha-blocker phentolamine and the beta blocker propranolol. The stimulation produced by 10(-6) M isoproterenol was not affected by 10(-5) M phentolamine but was completely prevented by 10(-5) M propranolol. The stimulation produced by 10(-5) M norepinephrine was completely blocked by the 10(-5) M propranolol and partially by 10(-5) M phentolamine. Catecholamines had no effect on the normally small Na+ transport. When the Na+ transport was previously increased by amphotericin B, epinephrine and isoproterenol produced a small and inconsistent stimulatory effect. Norepinephrine was without effect. It is concluded that both alpha- and beta-adrenergic receptors are present in the frog cornea and that the Cl- transport is increased by the stimulation of either receptor. The minimal effect on the Na+ transport further suggests the separation of pathways of the Cl- and Na+ transport in the frog cornea.

  • References
  • Citations11

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Chloride Ion Level
Z-Max
Biochemical Pathway
Resting Potentials
Catecholamines Measurement
Injection, Amphotericin B,50 MG Administered
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists
Entire Cornea
Epinephrine Measurement

About this Paper

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

© 2020 Meta ULC. All rights reserved