PMID: 40755Jan 1, 1979

Alpha- and beta-receptor blocking drugs in the treatment of hypertension

Current Problems in Cardiology
C V Ram, N M Kaplan

Abstract

The wide variety of antihypertensive agents now available allows considerable flexibility in the pharmacologic management of hypertension. The newly available alpha- and beta-adrenergic blocking agents have added considerably to this flexibility. Their safety and efficacy insure that they will find increasing use in the treatment of hypertension. The new postsynaptic alpha-receptor blocker prazosin, is generally free of the side effects that precluded the use of alpha-blockers which affected both pre- and postsynaptic receptors. Is is moderately effective and, excepting the problem of "first-dose" hypotension, it is usually well tolerated. Labetalol, a compound possessing both alpha- and beta-receptor blocking properties, has been found to be effective both as an oral therapy for chronic hypertension and as an intravenous agent in treating hypertensive crisis. Further experience with labetolol will determine its safety and efficacy for the long-term management of hypertension. Although the usefulness of beta-adrenergic receptor blocking agents in hypertension is unquestionable, the mechanism by which they lower the blood pressure remains in question. Most of our experience has been with propranolol, but other beta-blockers, now...Continue Reading

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Related Concepts

Labetalol
Thyroid Crisis
Sympathetic Nervous System
Hypertensive Crisis
Adrenergic alpha-Antagonists
Coronary Arteriosclerosis
ADRB2 gene
Metoprolol
Hypertensive Disease
Beta-adrenergic receptor

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