PMID: 9179623Feb 1, 1997Paper

Alpha-1-acid (AAG, orosomucoid) glycoprotein: interaction with bacterial lipopolysaccharide and protection from sepsis

Inflammation
D F MooreC M Tsai

Abstract

In the acute phase response to a variety of insults a rise in the levels of the acute phase proteins, including elevations of serum alpha 1 acid glycoprotein (AAG) occurs. The physiological role of AAG is unknown, however, the time course of AAG production in the acute phase response together with its strong affinity for basic compounds suggests that AAG may function as an immune modulator to bind both exogenous and endogenous inflammatory mediators. Using E. coli lipopolysaccharide (LPS), an initiator of the acute inflammatory response associated with septic shock, we demonstrate that AAG-LPS complexes can activate mouse macrophages in vitro. In a mouse animal model of sepsis, AAG was shown to protect against meningococcal endotoxin. To pursue the mechanism of AAG action we demonstrated that AAG interacts directly with LPS using dynamic light scattering particle sizing and particle mobility. We also determined the enthalpy of interaction of AAG and LPS and showed that AAG leads to agglutination of LPS impregnated rabbit red blood cells. These studies suggest that AAG may function as an immune-modulator in the acute phase response, possibly by counter-regulating the activity of macrophage pro-inflammatory cytokines.

Citations

Sep 12, 2012·Journal of Biomedical Materials Research. Part a·Adrienne Chandler-TempleLisbeth Grøndahl
Jun 26, 2014·Expert Opinion on Drug Metabolism & Toxicology·Thomas J Velenosi, Bradley L Urquhart
Feb 9, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S RajasekaranK Dharmalingam
Mar 20, 2020·Journal of Clinical Medicine·Małgorzata MarajMarek Kuźniewski
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Mar 26, 2011·Journal of Biomedicine & Biotechnology·Teresa R McCurdyWilliam P Sheffield
Aug 15, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Teresa R McCurdyAlison E Fox-Robichaud
Nov 22, 2017·Antimicrobial Agents and Chemotherapy·Axel Dalhoff
Nov 7, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Péter KustánDiána Mühl
Apr 6, 2019·Current Protein & Peptide Science·Fabrizio Ceciliani, Cristina Lecchi
Sep 17, 2017·The Journal of Rheumatology·Lampros FotisPhillip I Tarr
Feb 28, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Louis Alex JulienSimon Colin Andrews
Dec 23, 2008·Journal of Animal Science·B N AmetajK A Beauchemin
Nov 4, 2000·Biochimica Et Biophysica Acta·T FournierD Porquet
Nov 4, 2000·Biochimica Et Biophysica Acta·L Lögdberg, L Wester
Nov 4, 2000·Biochimica Et Biophysica Acta·T Bratt
Dec 18, 2002·Cytokine & Growth Factor Reviews·Tino HochepiedClaude Libert
May 26, 2004·The Veterinary Journal·H MurataM Yoshioka
Jun 26, 2021·Frontiers in Physiology·Mario Ruiz
Jan 13, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Magdalena Orczyk-PawiłowiczIwona Katnik-Prastowska
Jul 26, 2008·The Veterinary Clinics of North America. Equine Practice·Mark V CrismanKurt L Zimmerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.