Alpha 1-adrenoceptor subtypes mediating adrenergic vasoconstriction in kidney, one-clip Goldblatt and deoxycorticosterone acetate-salt hypertensive rats

Journal of Cardiovascular Pharmacology
M Abdul Sattar, E J Johns

Abstract

We characterised the functional alpha 1-adrenoceptors involved in mediating adrenergic vasoconstrictor responses in kidney of two-kidney one-clip (2K1C) Goldblatt and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In sodium pentobarbital-anaesthetised rats, frequency- and dose-dependent renal vasoconstrictor responses were obtained by direct electrical renal nerve stimulation, close renal arterial administration of phenylephrine (PE), and methoxamine. Administration of amlodipine, a dihydropyridine calcium channel antagonist (bolus dose of 200 and 400 micrograms/kg and an infusion of 50 and 100 micrograms/kg/h, respectively) and the alpha 1-adrenoceptor antagonist 5-methylurapidil (5 micrograms/kg plus 1.25 micrograms/kg/h and twice this dose) suppressed renal nerve-, PE-, and methoxamine-induced vasoconstrictions 14-70% (p < 0.05-0.001) in 2K1C Goldblatt and DOCA-salt hypertensive rats. The alpha 1B-adrenoceptor alkylating agent, chloroethylclonidine (5 micrograms/kg plus 1.25 micrograms/kg/h and twice this dose) caused significant attenuation (p < 0.001) of renal nerve-induced vasoconstriction by 19-23% in DOCA-salt hypertensive rats but did not affect PE- and methoxamine-induced vasoconstriction in either 2K1C Go...Continue Reading

Citations

Jul 8, 2011·The British Journal of Nutrition·Mohammed H AbdullaHassaan A Rathore
Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·Abdul H KhanEdward J Johns
Jan 25, 2008·Acta Pharmacologica Sinica·Md Abdul Hye KhanEdward James Johns
Sep 4, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Md Abdul Hye KhanEdward James Johns
Jul 5, 2008·Autonomic & Autacoid Pharmacology·M H AbdullaE J Johns
Feb 2, 2011·Neurourology and Urodynamics·Ibrahim M SalmanEdward J Johns
Mar 6, 2007·Journal of the American College of Cardiology·Willem J RemmeMary Ann Lukas
Feb 8, 2000·American Journal of Physiology. Renal Physiology·M SalomonssonW J Arendshorst

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