In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.
An analysis of some factors influencing alpha-adrenoceptor feed-back at the sympathetic junction in the rat heart
Effects of isoprenaline and phenylephrine on energy-rich phosphate compounds and glucose-6-phosphate in smooth and cardiac muscle
A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat
Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility
A comparison of pre- and post-junctional potencies of several alpha-adrenoceptor agonists in the cardiovascular system and anococcygeus muscle of the rat. Evidence for two types of post-junctional alpha-adrenoceptor
The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists
Calcium antagonists inhibit positive chronotropic responses to alpha 1-adrenoceptor activation in rat isolated atria
Evidence for postsynaptic alpha 1- and alpha 2-adrenoceptors mediating catecholamine-induced negative chronotropic ventricular responses in the conscious dog
Mechanisms of the in vitro effects of amphetamine on rat sinus node automaticity and membrane potentials of atrial fibers
Involvement of alpha 1-adrenoceptors in chronotropic responses to endogenously released amines in the pithed rat
Examination of cardiac alpha-adrenoceptors from pharmacological responses and radioligand binding. Comparison of rat and guinea pig tissues
External Ca-independent release of norepinephrine by sympathomimetics and its role in negative feedback modulation
Antiarrhythmic effect of the selective I1-imidazoline receptor modulator moxonidine on ouabain-induced cardiac arrhythmia in guinea pigs
Selective stimulation of vascular postjunctional alpha-adrenoreceptors by (-)-amidephrine in rats and cats
Effects of prazosin, phentolamine and yohimbine on noradrenergic transmission in the rat right ventricle in vitro
Peripheral cardiovascular alpha- and beta-adrenergic effects of some hypotensive and bradycardic arylalkyl imidazole derivatives in the rat
Effect of artificial respiratory volume on the cardiovascular responses to an alpha 1- and an alpha 2-adrenoceptor agonist in the air-ventilated pithed rat
Effects of alpha-adrenoceptor agonists on cardiac output and its regional distribution in the pithed rat
alpha 1-adrenoceptor activation can increase heart rate directly or decrease it indirectly through parasympathetic activation
Do both adrenaline and noradrenaline stimulate cardiac alpha-adrenoceptors to induce positive inotropy of rat atria?
Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.
Adrenergic Receptors: Trafficking
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.