PMID: 6982216Jan 1, 1982Paper

Alpha-1-antitrypsin (alpha 1AT) phenotypes and PiM subtypes in Italy. Evidence of considerable geographic variability

Human Genetics
G MassiP Auconi

Abstract

Genetic typing of alpha 1AT was performed in 3751 individuals from Italian towns. The following was observed: (a) The pathologic phenotypes (SZ, MZ, ZZ) appeared to decrease progressively from northern to southern Italy; (b) the distribution of the PiM suballeles showed considerable geographic variability, but the suballele M2 was more frequently encountered in southern Italy; and (c) in the large cities of southern Italy, the frequency of the deficiency more closely resembled that found in northern Italy than that of the remaining populations of the south.

References

May 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·M K Fagerhol, C B Laurell
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·M K Fagerhol, O W Tenfjord
Jan 1, 1980·Human Genetics·J ConstansC Gouaillard

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Citations

Jan 21, 1995·Forensic Science International : Synergy·S ShindoA B Miura
Jan 1, 1997·American Journal of Human Biology : the Official Journal of the Human Biology Council·Maria FuciarelliGian Franco De Stefano
Jun 15, 1991·American Journal of Medical Genetics·S Nevo, H Cleve
Aug 28, 2020·Reviews in Medical Virology·Mariana Braccialli de LoyolaEnrique R Argañaraz

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