Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina

Experimental Eye Research
Gustavo OrtizJuan E Gallo

Abstract

Diabetic retinopathy (DR) is the most common cause of blindness in the working age population. Early events of DR are accompanied by neurodegeneration of the inner retina resulting in ganglion cell loss. These findings together with reduced retinal thickness are observed within the first weeks of experimental DR. Besides, an inflammatory process is triggered in DR in which the innate immune response plays a relevant role. Alpha 1 antitrypsin (AAT), an inhibitor of serine proteases, has shown anti-inflammatory properties in several diseases. We aimed at evaluating the use of AAT to prevent the early changes induced by DR. Diabetic AAT-treated mice showed a delay on ganglion cell loss and retinal thinning. These animals showed a markedly reduced inflammatory status. AAT was able to preserve systemic and retinal TNF-α level similar to that of control mice. Furthermore, retinal macrophages found in the AAT-treated diabetic mouse exhibited M2 profile (F4/80+CD206+) together with an anti-inflammatory microenvironment. We thus demonstrated that AAT-treated mice show less retinal neurodegenerative changes and have reduced levels of systemic and retinal TNF-α. Our results contribute to shed light on the use of AAT as a possible therapeu...Continue Reading

References

Feb 12, 1998·The New England Journal of Medicine·A D Luster
Feb 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonia M JoussenAnthony P Adamis
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy S Olson, Klaus Ley
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Pamela M MartinSylvia B Smith
Mar 31, 2007·American Journal of Respiratory Cell and Molecular Biology·Andrew ChurgJoanne L Wright
Feb 13, 2008·Archives of Ophthalmology·Hui-yang ZengMark O M Tso
Jan 20, 2009·Investigative Ophthalmology & Visual Science·Hille W van DijkMichael D Abràmoff
Jun 6, 2009·The New England Journal of Medicine·Manuel G CosioAlvar Agusti
Feb 5, 2010·Investigative Ophthalmology & Visual Science·Hille W van DijkMichael D Abràmoff
May 4, 2010·Investigative Ophthalmology & Visual Science·Qiuhong LiWilliam W Hauswirth
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Debra L LaskinJeffrey D Laskin
Jun 4, 2011·Progress in Retinal and Eye Research·Johnny Tang, Timothy S Kern
Mar 30, 2012·The New England Journal of Medicine·David A AntonettiThomas W Gardner
May 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eyal OzeriEli C Lewis
May 29, 2012·Molecular Medicine·Eli C Lewis
Jan 10, 2013·Annual Review of Immunology·Steven J Van Dyken, Richard M Locksley
Mar 30, 2013·Investigative Ophthalmology & Visual Science·Steven F Abcouwer, David A Antonetti
Apr 18, 2013·EMBO Molecular Medicine·Almudena Ortega-GómezOliver Soehnlein
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Aug 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Danny JonigkSabina Janciauskiene
Nov 29, 2013·Journal of Diabetes Research·Angela Ka Wai Lai, Amy C Y Lo
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
Sep 23, 2014·Chronobiology International·María Florencia González FleitasDamián Dorfman
Nov 26, 2015·Eye and Vision·Ryan LeeCharumathi Sabanayagam
Dec 5, 2015·Expert Review of Respiratory Medicine·Killian HurleyNoel G McElvaney
Apr 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Elliott H SohnMichael David Abràmoff
Nov 29, 2016·Investigative Ophthalmology & Visual Science·Joana Tavares FerreiraLuís Abegão Pinto
May 13, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Ross G EdgarAlice M Turner
Jun 3, 2017·Vision Research·Heping Xu, Mei Chen
Jul 1, 2017·BMC Biology·Siamon Gordon, Annette Plüddemann
Dec 21, 2017·Investigative Ophthalmology & Visual Science·Sangeetha SrinivasanNathan Efron

❮ Previous
Next ❯

Citations

Apr 2, 2020·International Journal of Molecular Sciences·María Constanza PotilinskiJuan Eduardo Gallo
Jan 29, 2019·Frontiers in Neuroscience·Prahalathan PichavaramSubhadra Priya Narayanan
Apr 20, 2021·Frontiers in Cardiovascular Medicine·Jordan R YaronAlexandra R Lucas
Jun 22, 2021·Journal of Diabetes Research·Shani PillarAndrzej Grzybowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Investigative Ophthalmology & Visual Science
Hille W van DijkMichael D Abràmoff
Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
C M Habibullah, G L Somoyajulu
Journal of Photochemistry and Photobiology. B, Biology
Ioannis Kokkinopoulos
Investigative Ophthalmology & Visual Science
Hille W van DijkMichael D Abràmoff
© 2022 Meta ULC. All rights reserved