PMID: 6978153Mar 4, 1982Paper

alpha 1-Antitrypsin microheterogeneity. Isolation and physiological significance of isoforms

Biochimica Et Biophysica Acta
L VaughanR W Carrell

Abstract

alpha 1-Antitrypsin has a microheterogeneity evident on isoelectric focusing as three major and several minor bands. We have identified the carbohydrate structures of the major bands; band 6 (isoform I) has three bi-antennary sidechains, band 4 (isoform II) has two bi- and one tri-antennary and band 2 (isoform III) has one bi- and two tri-antennary sidechains. The identity of the isoforms with the bands permitted their measurement in plasma by photometric scanning of the electrofocused gels. In healthy controls the levels of isoforms I, II and III were relatively constant and in the proportions of 5, 4 and 1, respectively. A marked change occurred during inflammation and oestrogen stress with isoforms II and III accounting for most of the increase in alpha 1-antitrypsin. One possible consequence of the changed proportions was shown to be the increased catabolism of the partially desialylated tri-antennary isoforms compared to that of the predominant bi-antennary form of the healthy individual.

References

Sep 21, 1978·Biochimica Et Biophysica Acta·J S Marshall, S Williams
Feb 1, 1978·European Journal of Biochemistry·J O JeppssonM Fagerhol
Jan 1, 1978·Journal of Biochemistry·M MoriiT Ikenaka
Aug 1, 1978·Biochemical Genetics·A Yoshida, M Wessels
Sep 1, 1975·European Journal of Biochemistry·C B LaurellE Thulin
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
May 7, 1968·Journal of Chromatography·W F Lehnhardt, R J Winzler
Oct 16, 1980·Biochemical and Biophysical Research Communications·P S Wong, J Travis
Dec 7, 1981·FEBS Letters·R W CarrellD R Boswell
Nov 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·H S FRIEDMAN

❮ Previous
Next ❯

Citations

Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H KataokaM Koono
Jan 1, 1989·European Journal of Pediatrics·K Heyne, J Henke-Wolter
Jan 1, 1988·Archives of Dermatological Research·D BarszczW Gliński
Jun 1, 1987·International Journal of Peptide and Protein Research·L Karic, C B Glaser
Apr 1, 1987·Bioscience Reports·R C Foreman
Jul 1, 1985·The British Journal of Nutrition·E C LewisJ Coppes
Jul 1, 1983·European Journal of Biochemistry·T AndusP C Heinrich
Apr 1, 1996·Journal of Gastroenterology and Hepatology·Y SuzukiH Asakura
Jan 14, 2011·Current Medical Research and Opinion·F Kueppers
Jan 1, 1994·Annals of Human Genetics·D B WhitehouseD A Hopkinson
Jun 25, 1998·Electrophoresis·N H PackerA A Gooley
Nov 2, 2018·American Journal of Respiratory Cell and Molecular Biology·Jingxu GuoWei Li
Feb 6, 2020·Journal of Clinical Medicine·Rocío Fuertes-MartínNúria Amigó
Jul 22, 1982·Nature·R W CarrellD R Boswell
Apr 17, 2012·Expert Opinion on Biological Therapy·Manish MohankaJames K Stoller
Oct 1, 2007·Expert Opinion on Medical Diagnostics·Marcin P KaczorAndrew Szczeklik
Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona ViglioJan Stolk
Jun 15, 2006·Amino Acids·E KarnaukhovaB Golding
Mar 29, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·P S HartB Wolf
Jun 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·G A Turner
Aug 31, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·B MalletC Arnaud
Jan 1, 1983·The International Journal of Biochemistry·A PellegriniR von Fellenberg
May 1, 1988·Journal of Biochemical and Biophysical Methods·L MiribelP Arnaud
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S D Patterson
Jun 1, 1987·Molecular and Cellular Endocrinology·U Hilgenfeldt, R Schott

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.