Nov 19, 1977

alpha 1-antitrypsin phenotypes in fibrosing alveolitis and rheumatoid arthritis

Lancet
D M GeddesA M Ward

Abstract

alpha 1-antitrypsin (alpha 1-A.T.) phenotypes were determined in 55 patients with rheumatoid arthritis (R.A.), 33 patients with R.A. and either obstructive airways disease or recurrent chest infections, 49 patients with fibrosing alveolitis (F.A.), 22 patients with R.A. and F.A., and 200 healthy controls. A highly significant increase in the frequency of MZ phenotype was found among patients with F.A., both with and without R.A. Patients with R.A. alone had a normal distribution of phenotypes. Inherited modification of immune function may predispose to F.A. Alternatively, lowered levels of alpha 1-A.T. associated with non-M phenotypes may predispose to tissue damage with subsequent fibrosis.

  • References1
  • Citations43

References

  • References1
  • Citations43

Citations

Mentioned in this Paper

Pulmonary Alveolar Structure
Pulmonary Fibrosis
Rheumatoid Arthritis
Experimental Lung Inflammation
Zemaira
Alpha 1-Antitrypsin Deficiency
Alleles
Airway Obstruction

About this Paper

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