Mar 23, 2004

Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha

Brain Research
Amy E RenauldR N Spengler


Activation of the alpha(2)-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-alpha (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in alpha(2)-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.

Mentioned in this Paper

Tumor Necrosis Factor-alpha
Regulation of Tumor Necrosis Factor Production
Adrenergic Receptor
Cyclic AMP, (R)-Isomer
Adrenergic receptor alpha(2a)
Metabolic Inhibition
TNF gene

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