Mar 23, 2004

Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha

Brain Research
Amy E RenauldR N Spengler

Abstract

Activation of the alpha(2)-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-alpha (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in alpha(2)-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.

Mentioned in this Paper

Colforsin
Necrosis
Tumor Necrosis Factor-alpha
Neurons
Regulation of Tumor Necrosis Factor Production
Adrenergic Receptor
Cyclic AMP, (R)-Isomer
Adrenergic receptor alpha(2a)
Metabolic Inhibition
TNF gene

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