Alpha 2-adrenoceptors determine the response to nitric oxide inhibition in the rat glomerulus and proximal tubule.

Journal of the American Society of Nephrology : JASN
S C Thomson, V Vallon

Abstract

Arginine-derived nitric oxide exerts control over the processes of glomerular filtration and tubular reabsorption. The tonic influence of nitric oxide over both of these is eliminated by renal denervation. The hypothesis that the renal nerves function, in this regard, via the activation of alpha 2-adrenoceptors was tested by renal micropuncture. The physical determinants of glomerular filtration and proximal tubular reabsorption were assessed in Munich-Wistar rats before and during the administration of the nitric oxide synthase inhibitor NG-monomethyl L-arginine (L-NMMA). In one set of studies, the systemic infusion of the alpha 2-agonist B-HT 933 rendered nephron GFR, nephron plasma flow, and proximal reabsorption sensitive to reduction by L-NMMA after renal denervation. In a second set of studies, the infusion of the alpha 2 receptor antagonist, yohimbine, to rats with renal nerves intact was found to suppress the effects of L-NMMA on nephron plasma flow and proximal reabsorption. The effects of L-NMMA on nephron GFR and nephron plasma flow, afferent and efferent arteriolar resistances, and proximal reabsorption correlated with the level of underlying alpha 2-adrenergic activity. The activation of renal alpha 2-adrenoceptors...Continue Reading

Citations

Apr 8, 1998·Current Opinion in Nephrology and Hypertension·C Thorup, A E Persson
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·P J Young, J H Miller
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·M A CostaC T Arranz
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Maria de los Angeles CostaC T Arranz
Feb 14, 1998·Kidney International·R C Blantz

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