PMID: 8967779Mar 1, 1996Paper

alpha 2-Antiplasmin and plasminogen activator inhibitors in healing human skin wounds

Archives of Dermatological Research
B M SchaeferM D Kramer

Abstract

Mechanical injury of tissues is followed by the formation of a provisional fibrin matrix, which is later replaced by granulation tissue. The fibrinolytic proteinase, plasmin, is thought to contribute to the displacement of the primary matrix. Plasmin is generated from the ubiquitous proenzyme plasminogen by plasminogen activators. The system of plasminogen activation is controlled at several levels: plasminogen activator inhibitors (PAI-1 and PAI-2) counteract the activity of plasminogen activators and alpha 2-antiplasmin inhibits the activity of plasmin. In order to elucidate the mechanisms that regulate the plasminogen activator system in healing human skin wounds, we performed the immunohistological study reported here. The plasmin inhibitor alpha 2-antiplasmin and PAI-2 were found in the primary fibrin-rich matrix and in the granulation tissue. alpha 2-Antiplasmin was diffusely distributed in the tissue and its distribution correlated with the presence and localization of plasmin(ogen) except that, in contrast to plasmin(ogen), the alpha 2-antiplasmin was apparently not cell-associated. The stainings for PAI-2 increased with time and paralleled the development of the cellular infiltrate. PAI-2 was found in association with ...Continue Reading

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Citations

Jul 10, 2003·Survey of Ophthalmology·Volker Schuster, Stefan Seregard
May 1, 1997·Expert Opinion on Investigational Drugs·P Charlton
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C M FerrierG N van Muijen
Mar 23, 1999·The Annals of Otology, Rhinology, and Laryngology·M P SchönermarkT Lenarz
Jan 26, 2006·Journal of Dental Research·P C Smith, J Martínez
Feb 19, 2014·International Journal of Molecular Medicine·Marzena Wyganowska-ŚwiątkowskaJerzy Jankun
Jul 27, 2001·The Journal of Biological Chemistry·D KesslerB Eckes
Apr 8, 2019·International Journal of Cosmetic Science·R SchützD Imfeld

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