PMID: 26323451Sep 2, 2015Paper

Alpha-2-Macroglobulin Levels in Gingival Crevicular Fluid Pre- and Post-scaling and Root Planing with Adjunctive Tetracycline Fibers in Chronic Periodontitis: A Randomized Controlled Trial

The Journal of Contemporary Dental Practice
Shivjot ChhinaSaurabh Juneja

Abstract

This split-mouth clinical study aimed to investigate levels of alpha-2-macroglobulin (a2M) in gingival crevicular fluid (GCF) of chronic periodontitis patients pre- and post-scaling and root planing (SRP) with or without adjunctive use of tetracycline fibers. In 30 patients of chronic periodontitis, samples of GCF were collected from the gingival sulcus before SRP. Recording of clinical parameters was conducted. This was followed by local drug delivery (LDD) of tetracycline fibers in test sites. In control sites, no LDD was done. Second samples of GCF were taken 90 days after treatment. Samples of crevicular fluid were analyzed to determine the levels of a2m. A gain of clinical attachment (CAL) of 3.30 mm for SRP and LDD and for SRP alone was 1.62 mm (p < 0.001). The pocket probing depth was significantly decreased by 2.43 mm for SRP and LDD and for SRP alone was 1.61 mm (p < 0.001) after 90 days. Alpha-2-macroglobulin was significantly reduced in GCF by SRP and SRP and LDD after 90 days (p < 0.001). Clinical and biochemical variables showed a more favorable outcome when SRP was combined with LDD of tetracycline fibers in management of patients suffering from chronic periodontitis.

References

Jan 1, 1986·Journal of Clinical Periodontology·L Sandholm
Jan 1, 1988·Archives of Oral Biology·I CondacciP Baehni
Jan 1, 1970·Journal of Periodontology·S TureskyI Glickman
Apr 1, 1982·Infection and Immunity·I CondacciC Ahmad-Zadeh
Jan 1, 1983·Annual Review of Biochemistry·J Travis, G S Salvesen
Apr 1, 1982·Journal of Periodontology·R SaglieG L Pattison
Jan 1, 1995·Journal of Clinical Periodontology·R A Seymour, P A Heasman
Mar 1, 1997·Annals of Periodontology·I B Lamster
Feb 4, 2003·Journal of Dental Research·T E Van Dyke, C N Serhan
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS

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