PMID: 9105230Apr 1, 1997Paper

Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected

Anesthesiology
P FloodL Role

Abstract

The mechanisms of action of general anesthetics are not completely understood. Many general anesthetics are reported to potentiate gamma-aminobutyric acid (GABAA) and glycine receptors in the central nervous system (CNS) and to inhibit the muscle-type nicotinic acetylcholine receptor (nAChR). The effects of general anesthetics on another family of ligand-gated ion channel in the CNS, the nAChRs, have not been defined. Two types of CNS acetylcholine receptor, the alpha 4 beta 2 receptor or the alpha 7 homomeric receptor, were expressed heterologously in Xenopus laevis oocytes. Using the standard two-microelectrode voltage-clamp technique, peak acetylcholinegated current was measured before and after coapplication of isoflurane or propofol. Coapplication of either isoflurane or propofol with acetylcholine resulted in potent, dose-dependent inhibition of the alpha 4 beta 2 receptor current with median inhibitory concentrations of 85 and 19 microM, respectively. The inhibition of the alpha 4 beta 2 receptor by both isoflurane and propofol appears to be competitive with respect to acetylcholine. The alpha 7 receptor current was not effected by either anesthetic. The CNS-type nAChRs are differentially affected by isoflurane and propo...Continue Reading

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References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D BertrandD Rungger
Feb 17, 1994·Nature·N P Franks, W R Lieb
Feb 1, 1995·British Journal of Pharmacology·P Charlesworth, C D Richards
Aug 1, 1994·The International Journal of Neuroscience·N BohnenL T Kurland
Sep 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD

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Citations

Nov 19, 2002·Journal of Neurobiology·Edna F R PereiraEdson X Albuquerque
Dec 13, 1997·Molecular Neurobiology·J Lindstrom
Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A FassoulakiC Derveniotis
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Apr 27, 2007·Journal of Anesthesia·David O Warner
Jul 2, 2003·Biochimica Et Biophysica Acta·Maurizio Gattoni, Alberto Boffi
Jan 8, 2000·Journal of Neuroimmunology·B BalestraC Gotti
Feb 19, 2002·Brain Research Bulletin·Edömer TassonyiDaniel Bertrand
Feb 27, 1999·Toxicology Letters·N P Franks, W R Lieb
Feb 27, 1999·Toxicology Letters·P Flood, L W Role
Feb 27, 1999·Toxicology Letters·T NarahashiJ Z Yeh
Jun 6, 2003·The Veterinary Journal·L BergamascoA Jaggy
Sep 21, 2010·Quarterly Reviews of Biophysics·Andrew J ThompsonSarah C R Lummis
Jan 24, 2013·Journal of the American Chemical Society·David MowreyPei Tang
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
Sep 19, 2002·British Journal of Pharmacology·Ambuja S BaleJohn J Woodward
May 23, 2003·The New England Journal of Medicine·Jason A CampagnaStuart A Forman
Jan 10, 2013·The Journal of Biological Chemistry·Selwyn S JayakarJonathan B Cohen
Jun 11, 2009·British Journal of Anaesthesia·H C Hemmings
Mar 5, 2004·American Journal of Therapeutics·Douglas V BrownRobert Barkin
Jul 12, 2008·International Anesthesiology Clinics·Christa J Van DortRalph Lydic
Jun 6, 2009·European Journal of Anaesthesiology·Andrea Kopp LugliChristoph H Kindler
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·T YamakuraR A Harris
May 29, 2002·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Dec 31, 2002·Anesthesia and Analgesia·Erin M RadaPamela Flood
Jul 24, 2004·Anesthesia and Analgesia·Akira KitamuraToshio Narahashi
Mar 23, 2005·Anesthesia and Analgesia·Thomas J RowleyPamela Flood
Jul 23, 2005·Anesthesia and Analgesia·Julia O UdeskyPamela Flood

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