PMID: 2498836May 1, 1989Paper

Alpha-adrenergic activation of the muscarinic K+ channel is mediated by arachidonic acid metabolites

Pflügers Archiv : European journal of physiology
Y KurachiM Ui

Abstract

Phenylephrine (10 microM), added in the bathing solution, stimulated the cardiac muscarinic K+ channel (IK.ACh) in the cell-attached patch. The pipette solution contained 10 microM atropine and 100 microM theophylline to block the muscarinic acetylcholine and adenosine receptors, respectively. The channel activation induced by phenylephrine was blocked by prazosin, an alpha 1-antagonist, indicating that alpha 1-adrenergic receptor mediates the response. Phenylephrine-induced activation was prevented by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and AA-861, a 5-lipoxygenase inhibitor, but was not affected by indomethacin, a cyclooxygenase inhibitor. These observations suggest that 5-lipoxygenase metabolites of arachidonic acid may be involved in the alpha-adrenergic activation of IK.ACh.

Citations

Aug 1, 1992·Pflügers Archiv : European journal of physiology·A P BraunW R Giles
Nov 1, 1993·Pflügers Archiv : European journal of physiology·M Bünemann, L Pott
Jun 1, 1994·Journal of Biomedical Science·M.-J. SuS.-H. Chu
Sep 1, 1992·Progress in Neurobiology·Y KurachiT Nakajima
Jun 1, 1995·Current Opinion in Neurobiology·K D Wickman, D E Clapham
Oct 24, 1998·Progress in Biophysics and Molecular Biology·E Carmeliet, K Mubagwa
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Jan 16, 1998·Cellular Signalling·N Dascal
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N DascalH A Lester
Jun 1, 1991·The Journal of General Physiology·K OkabeA M Brown
Jun 9, 2000·Annual Review of Physiology·M V CohenJ M Downey
Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Dec 24, 1997·Nature·C W VaughanM J Christie
Sep 17, 2019·Cellular Signalling·Anne NiemeyerMarie-Cecile Kienitz
Apr 1, 1994·The American Journal of Physiology·C F Lo, G E Breitwieser
Mar 11, 1991·Trends in Neurosciences·R W OrdwayJ V Walsh

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