Aug 1, 1976

Alpha-adrenergic activity of N,N-dimethyldopamine (DMDA)

European Journal of Pharmacology
J M KitzenJ P Long


The autonomic and cardiovascular activity of N,N-dimethyldopamine (DMDA) was studied in the dog and rabbit. DMDA appears to be a postganglionic sympathetic alpha-adrenoceptor agonist since it consistently caused vasconstriction in several isolated vascular beds, even in the presence of ganglionic blockade. The pressor activity of DMDA was attenuated by the alpha-adrenergic antagonist phentolamine. Calculated pA2 values for phentolamine against both DMDA and norepinephrine in isolated rabbit arteries were in close agreement. DMDA inhibits cardioaccelerator nerve stimulation induced chronotropic responses by a mechanism which appears to be alpha-adrenergic in the dog.

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Mentioned in this Paper

Arterial System
Blood Vessel
N, N-dimethyldopamine
Regional Blood Flow
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists

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