alpha-Adrenergic blocking properties of quinine HCl

European Journal of Pharmacology
T E MeccaR W Caldwell

Abstract

In the anesthetized dog, quinine HCl (50 mg/kg, i.v.) infused over a 20 min period produced 1 22% maximum decrease in diastolic blood pressure, a 53% increase in pulse pressure and a 52% increase in myocardial contractile force. The initial positive inotropic response was maximal in the first 5--15 min of the quinine infusion and decreased to near control levels 40 min following the quinine infusion. Quinine caused a marked reduction in the noradrenaline (NA) pressor response, blockade of the adrenaline (A) pressor response, partial blunting of the angiotensin II (AII) pressor effect but no change in the depressor effect of isoprenaline (I). The positive inotropic effects of CaCl2 were reduced and the duration of contractile action to both I and CaCl2 was significantly prolonged by quinine. In isolated rabbit thoracic aortic strips, quinine produced a parallel, dose-related shift of the concentration-response curve for NA to the right but did not affect the maximum responses. A pA2 of 4.91 was estimated by the method of Schild. The determined line had a slope of -0.84 which is similar to a theoretical slope of -1.0 and indicates a direct relationship between the number of receptors occupied and the contractile response. The res...Continue Reading

References

Jan 1, 1976·Biochemical Pharmacology·D C Pang, F N Briggs
Feb 15, 1978·Biochemical Pharmacology·C R Gattass, L De Meis
Dec 1, 1978·Toxicology and Applied Pharmacology·R J Marshall, J A Ojewole
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Mar 1, 1964·The Journal of Pharmacy and Pharmacology·E J ARIUENS, A M SIMONIS
Sep 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD
Oct 1, 1947·Proceedings of the Society for Experimental Biology and Medicine·W B YOUMANS, V M RANKIN

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Citations

Oct 28, 1983·European Journal of Pharmacology·R W CaldwellC B Nash
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·A Sclafani, J A Toris
Jul 19, 2014·European Journal of Pharmacology·Martijn L MansonMikael Adner
Dec 1, 1987·British Journal of Pharmacology·D GebremedhinK Magyar
Mar 1, 1983·The American Journal of Physiology·T Tamagawa, J C Henquin

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