Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats

The Journal of Clinical Investigation
D J SheridanP B Corr


Alpha compared to beta adrenergic contributions to dysrhythmias induced by left anterior descending coronary occlusion and by reperfusion were assessed in chloralose-anesthetized cats (n = 96). Alpha receptor blockade with either phentolamine or prazosin significantly reduced the number of premature ventricular complexes during coronary reperfusion (321 +/- 62-14 +/- 10 premature ventricular complexes, P less than 0.001), abolished early ventricular fibrillation (from 25% in controls to 0%), and prevented the increase in idioventricular rate seen with coronary reperfusion. However, beta-receptor blockade was without effect. Ventricular dysrhythmias induced by coronary occlusion alone (without reperfusion) were attenuated markedly by alpha-receptor blockade under conditions in which perfusion (measured with radiolabeled microspheres) within ischemic zones was not affected. Alternative sympatholytic interventions including pretreatment with 6-hydroxydopamine to deplete myocardial norepinephrine from 8.8 +/- 1.4 to 0.83 +/- 0.2 ng/mg protein and render the heart unresponsive to tyramine (120 microgram/kg) attenuated dysrhythmias induced by both coronary occlusion and reperfusion in a fashion identical to that seen with alpha-recep...Continue Reading


Jan 1, 1978·The Journal of Clinical Investigation·P B CorrB E Sobel
Aug 1, 1977·Circulation Research·M VassalleJ H Stuckey
Jun 1, 1977·Prostaglandins·W HsuehP Needleman
Jan 1, 1976·Journal of Electrocardiology·M VassalleJ H Stuckey
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Jun 1, 1966·American Heart Journal·A S Harris
Apr 1, 1970·Cardiovascular Research·P A EbertD C Sabiston
Jan 1, 1971·British Heart Journal·L GouldM Zahir
Sep 1, 1968·Anesthesiology·E G Dowdy, K Kaya
Oct 1, 1961·British Journal of Pharmacology and Chemotherapy·B G Benfey, K GREEFF


Feb 1, 1991·Journal of Clinical Pharmacology·E M Vaughan Williams
Aug 1, 1990·Cardiovascular Drugs and Therapy·D J Hearse
Mar 1, 1991·Cardiovascular Drugs and Therapy·D J Hearse
Dec 1, 1989·Pflügers Archiv : European journal of physiology·A ZiadaK R Tyler
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M BoucherP Duchene-Marullaz
Nov 1, 1987·Pflügers Archiv : European journal of physiology·P BorgdorffA Cevese
Jun 7, 1995·Molecular and Cellular Biochemistry·M Yasutake, M Avkiran
Dec 3, 1990·Molecular and Cellular Biochemistry·T KawaiT Satake
Jun 1, 1994·Journal of Biomedical Science·M.-J. SuS.-H. Chu
Jan 1, 1991·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·A R ZouH Pei
May 1, 1983·Irish Journal of Medical Science·B SilkeS H Taylor
Oct 16, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Jacek SapaKatarzyna Kulig
Jun 10, 2008·Pflügers Archiv : European journal of physiology·Johannes P HofgaardMorten Schak Nielsen
Dec 17, 1981·European Journal of Pharmacology·S A SegalR A Gillis
Aug 7, 1986·European Journal of Pharmacology·D J WilberB R Lucchesi
Dec 4, 1990·European Journal of Pharmacology·J HasegawaH Mashiba
Apr 17, 1991·European Journal of Pharmacology·H TodtG Raberger
Oct 27, 1980·Life Sciences·I Cavero, A G Roach
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Jan 1, 1984·Pharmacology & Therapeutics·E Winslow
Jul 1, 1989·Journal of the American College of Cardiology·J CincaA Salas-Caudevilla
May 1, 1989·Journal of the American College of Cardiology·D P Zipes
May 1, 1994·Journal of the American College of Cardiology·S Krishnan, M N Levy
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H KotakeH Mashiba
Jan 1, 1988·Free Radical Biology & Medicine·A S Manning
Jan 1, 1990·Free Radical Biology & Medicine·Y J ApplebaumM Chevion
Jan 1, 1990·Free Radical Biology & Medicine·Arpad TosakiB Ebert
Jan 11, 1991·Free Radical Biology & Medicine·L Lacoursiere, J H Kingma
Jun 12, 2003·European Journal of Pharmacology·Miklos VecsernyesArpad Tosaki
Dec 1, 1984·Journal of Molecular and Cellular Cardiology·R BolliR R Miller
Dec 1, 1986·Journal of Molecular and Cellular Cardiology·W H van GilstH Wesseling

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